Special Issue "Chemopreventive Effects of Dietary Natural Products on Modulation of Xenobiotic-Metabolizing Enzymes"

A special issue of Catalysts (ISSN 2073-4344). This special issue belongs to the section "Biocatalysis".

Deadline for manuscript submissions: 30 June 2021.

Special Issue Editor

Prof. Dr. Hsien-Tsung Yao
Guest Editor
Department of Nutrition, China Medical University, 91 Hsueh-shih Road, Taichung 404, Taiwan
Interests: xenobiotic-metabolizing enzymes; detoxification; functional foods; dietary natural products

Special Issue Information

Dear Colleagues,

Humans today frequently suffer from the effects of environmental pollution (e.g., polycyclic aromatic hydrocarbons, PAHs), drugs, toxic chemicals, and food contamination. When entering the human body, these compounds are called xenobiotics, and exposure to these xenobiotics may damage human organs. Impaired detoxification ability may lead to the progress and development of various chronic diseases, including cancer.

Xenobiotic-metabolizing enzymes include phase I oxidation enzymes (e.g., cytochrome P450, CYP) and phase II conjugation enzymes that are involved in the detoxification of xenobiotics. The liver is one of the most important organs responsible for the detoxification of xenobiotics. In some cases, xenobiotics are metabolized by phase I enzymes to form reactive metabolites and produce large amounts of reactive oxygen species (ROS). This may cause cellular oxidative stress. Some dietary natural products or phytochemicals can inhibit or induce nuclear receptors that can modulate the transcription of CYP enzymes and, thereafter, their enzyme activity. This may lead to bioactivation or detoxification of xenobiotics. In vitro and in vivo CYP enzyme inhibition and induction studies are used to evaluate natural product–xenobiotic interaction. Activation of nuclear factor erythroid 2 (NFE2)-related factor 2 (Nrf2) by dietary natural products or phytochemicals plays a critical role in promoting cellular phase II detoxifying enzymes and antioxidant defense systems.

This Special Issue aims to cover the most recent progress and advances in the field of natural products and xenobiotic-metabolizing enzymes. This includes experimental studies as well as human studies on how natural products exert their chemopreventive effects or chemical detoxification.

Prof. Dr. Hsien-Tsung Yao
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Catalysts is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • xenobiotic-metabolizing enzymes
  • cytochrome P450
  • dietary natural products
  • Nrf2
  • detoxification
  • functional foods
  • herbal medicines, beverage
  • vegetable
  • food/ beverage/herb–drug intercation

Published Papers

This special issue is now open for submission.
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