Special Issue "The Influence of Phase Transfer Catalysis (PTC) in the Synthesis of Bioactive Compounds"
Deadline for manuscript submissions: closed (31 October 2022) | Viewed by 2610
Interests: bioactive compounds; solvent-free synthesis; mechanochemistry; sonochemistry; synthesis in the presence of microwave radiation; phase transfer catalysis (PTC); green chemistry; serotonin receptor ligands; dopamine receptor ligands; API (active pharmaceutical ingredient)
Interests: molecular crystal engineering; solid state chemistry; hydrogen bonding; crystal polymorphism; solid networks; solid-state API (active pharmaceutical ingredient); molecular and ionic co-crystals; solvent-free reactions; DFT calculations
Interests: heterogeneous catalysis; sonochemistry; spectroscopy; structured reactors; metal–organic frameworks; zeolites; metal oxide catalysis
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In recent years, research efforts have focused on the search for methods of synthesis of bioactive compounds that are characterized by a simplicity of the individual stages of the process and the use of readily available and safe reagents while maintaining high selectivity and efficiency. Moreover, especially in larger-scale reactions, the aspect of limiting the amount of harmful and environmentally toxic byproducts and waste is important. All these conditions are met by phase transfer catalysis (PTC). A wide variety of reactions can be carried out under PTC conditions, such as alkylation, oxidation, reduction, elimination, hydrolysis, aliphatic and aromatic substitution, multiple bond addition, carbonyl addition, and many others. Additionally, it is possible to use PTC conditions both in classical methods of synthesis and in the presence of microwave radiation, ultrasounds or in mechanochemistry. The obtained products, often even unpurified, are characterized by high purity, which is extremely important in the case of bioactive compounds. All these advantages of the PTC method mean that it is now used more and more often in the synthesis of bioactive compounds.
This Special Issue aims to cover the most recent progress and advances in the field of synthesis of bioactive compounds under phase transfer catalysis conditions. This includes both reactions using the PTC method in one or more steps, aimed at the synthesis of new bioactive compounds, and processes aimed at the development of new alternative methods of known drugs.
Dr. Jolanta Jaśkowska
Dr. Edyta Pindelska
Dr. Przemysław Jodłowski
Manuscript Submission Information
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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Catalysts is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- phase transfer catalysis (PTC)
- bioactive compounds
- solvent-free synthesis
- synthesis in the presence of microwave radiation