Advanced Methods for Catalytic/Sustainable Amide or Peptide Formation

Dear Colleagues,

The amide bond represents one of the most important linkages in chemistry and constitutes a common motif in peptides, pharmaceuticals, and polymeric materials. Over the past few decades, many procedures for accomplishing amide formation have been developed, and this synthesis is still a contemporary challenge. However, the use of inefficient and often hazardous reagents associated with the unacceptable amounts of waste produced have led the members of the ACS Green Chemistry Institute® Pharmaceutical Roundtable to label amide bond formation as one of the most pressing targets for sustainable synthetic method development and to encourage academic research to this end. Therefore, it is highly desirable to develop improved processes for the synthesis of amide functionality performing these transformations catalytically or with improved atom efficiency, using more environmentally friendly solvents or reagents and robustness on scale, including reducing waste streams and simplifying processes. 

This Special Issue is aimed at reporting a broad survey of recent advances in sustainable amide bond formation and various approaches in the field. Furthermore, it will contain contributions describing multifaceted aspects of this area.

Dr. Maria Luisa Di Gioia
Prof. Antonio Procopio
Dr. Monica Nardi
Guest Editors

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