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Catalysts
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Recent Advances in Palladium-Catalyzed Organic Synthesis
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Recent Advances in Palladium-Catalyzed Organic Synthesis

A special issue of Catalysts (ISSN 2073-4344). This special issue belongs to the section "Catalysis in Organic and Polymer Chemistry".

Deadline for manuscript submissions: 15 September 2025 | Viewed by 3800

Special Issue Editors

Dr. Erqing Li

E-Mail Website
Guest Editor
College of Chemistry, Zhengzhou University, Zhengzhou 450001, China
Interests: palladium catalysis; asymmetric synthesis; cycloaddition; phosphine
Dr. Yue Wang

E-Mail Website
Guest Editor Assistant
College of Advanced Interdisciplinary Science and Technology (CAIST), Henan University of Technology, Zhengzhou 450001, China
Interests: palladium catalysis; organocatalysis; green synthesis

Special Issue Information

Dear Colleagues,

In recent decades, palladium catalysis has emerged as a powerful and reliable synthetic strategy for the construction of a wide range of pharmaceuticals and bioactive natural products. The chemistry of palladium catalysis is a promising field with many potential applications. Further research in this area is likely to lead to discoveries and advances in a variety of fields. These fields include, but are not limited to, the following:

  • Palladium-catalyzed allylation;
  • Palladium-catalyzed cross-coupling reactions;
  • Chirality and asymmetric palladium catalysis;
  • Dual catalysis involving palladium catalysts;
  • Palladium-catalyzed annulations.

In fact, all these prompt advances have significantly changed our world, and the chemistry of palladium catalysis is also of great importance to the understanding of biological systems, as well as the development of new materials and technologies.

This Special Issue will present the most recent and significant developments in palladium catalysis. Please join us in this endeavor to promote and disseminate ecofriendly practices in the field of organic synthesis as we work towards a more sustainable and environmentally conscious future. Original papers on the above topics and short reviews are welcome for submission.

If you would like to submit papers for publication in this Special Issue or have any questions, please contact the in-house Editor, Mr. Ives Liu (ives.liu@mdpi.com).

Dr. Erqing Li
Guest Editor

Dr. Yue Wang
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Catalysts is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • palladium catalysis
  • cross-coupling reactions
  • allylation
  • asymmetric catalysis
  • annulations
  • photoinduced palladium-catalyzed transformations
  • chiral palladium complexes

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (4 papers)

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Research

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11 pages, 911 KiB  
Communication
Sustainable Synthesis of α-Glucosidase Inhibitors by Gas-Free Pd-Carbonylation of Nature-Based Hydroxytyrosol
by Francesco Messa, Domenico Armenise, Anselma Liturri, Maria Grazia Perrone, Serena Perrone and Antonio Salomone
Catalysts 2025, 15(3), 202; https://doi.org/10.3390/catal15030202 - 21 Feb 2025
Viewed by 672
Abstract
This study outlines the sustainable synthesis of novel hydroxytyrosol (HT) and tyrosol (T) ester derivatives via a Pd-catalyzed alkoxycarbonylation of aromatic iodides. The high sustainability of the process is attributed to the use of (1) a solid carbon monoxide source, Mo(CO)6, [...] Read more.
This study outlines the sustainable synthesis of novel hydroxytyrosol (HT) and tyrosol (T) ester derivatives via a Pd-catalyzed alkoxycarbonylation of aromatic iodides. The high sustainability of the process is attributed to the use of (1) a solid carbon monoxide source, Mo(CO)6, in place of dangerous gaseous CO; (2) a biomass-derived organic solvent, CPME (cyclopentyl methyl ether); (3) naturally occurring hydroxylated compounds, such as HT and T, which could be derived from agricultural waste rather than produced from petroleum-based sources. The method enables the regioselective preparation of various HT and T esters in a short reaction time (4–8 h), under mild temperatures (80 °C), and with moderate-to-excellent yields (62–93%). Moreover, in vitro biological tests have demonstrated that, in addition to the well-known antioxidant properties typical of natural phenolic compounds such as HT and T, some of the newly synthesized derivatives have a safe profile and are effective inhibitors of the α-glucosidase with potential application in the management of hyperglycemia. This synthetic approach offers a promising strategy for exploring biologically relevant chemical space, bridging the gap between natural products and sustainable drug synthesis. Full article
(This article belongs to the Special Issue Recent Advances in Palladium-Catalyzed Organic Synthesis)
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18 pages, 1234 KiB  
Article
Palladium-Catalyzed Decarbonylative Nucleophilic Halogenation of Acid Anhydrides
by Tian Tian, Shuhei Uei, Weidan Yan and Yasushi Nishihara
Catalysts 2025, 15(2), 191; https://doi.org/10.3390/catal15020191 - 19 Feb 2025
Viewed by 807
Abstract
In this study, we developed a palladium-catalyzed decarbonylative nucleophilic halogenation reaction using inexpensive and readily available acid anhydrides as substrates. This approach effectively circumvents the instability of acyl chlorides and the low reactivity of acyl fluorides. The Pd/Xantphos catalyst system exhibited excellent compatibility [...] Read more.
In this study, we developed a palladium-catalyzed decarbonylative nucleophilic halogenation reaction using inexpensive and readily available acid anhydrides as substrates. This approach effectively circumvents the instability of acyl chlorides and the low reactivity of acyl fluorides. The Pd/Xantphos catalyst system exhibited excellent compatibility with the thermodynamically and kinetically challenging reductive elimination of C–X bonds (X = I, Br, and Cl) from Pd(II) intermediates. Notably, for electron-donating substrates, adopting an open system significantly improved the reaction efficiency. The positive effect of the open system may be due to the reversible nature of CO insertion and deinsertion, which helps direct the reaction toward the desired pathway by allowing the generated CO to exit the reaction system. Mechanistic studies suggest that the reaction proceeds through a highly reactive acyl halide intermediate, followed by a unimolecular fragment coupling (UFC) pathway via decarbonylation or an alternative pathway involving the formation of an activated anionic palladate complex in the presence of lithium halide. Full article
(This article belongs to the Special Issue Recent Advances in Palladium-Catalyzed Organic Synthesis)
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Review

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21 pages, 3928 KiB  
Review
Recent Advances in Palladium-Catalyzed Enantioselective Cyclization for the Construction of Atropisomers
by Xilong Wang, Wei Ren, Jingyi Zhang, Shunwei Zhao, Duo Zhou, Hui Chen and Tingting Liu
Catalysts 2025, 15(4), 320; https://doi.org/10.3390/catal15040320 - 27 Mar 2025
Viewed by 477
Abstract
Axially chiral structures have become increasingly common in modern materials and pharmaceuticals, especially as chiral ligands and organocatalysts, highlighting their growing significance. In the field of pharmaceutical research, there are several notable examples worth highlighting, such as the antibiotics vancomycin, Knipholone, and Mastigophorene [...] Read more.
Axially chiral structures have become increasingly common in modern materials and pharmaceuticals, especially as chiral ligands and organocatalysts, highlighting their growing significance. In the field of pharmaceutical research, there are several notable examples worth highlighting, such as the antibiotics vancomycin, Knipholone, and Mastigophorene A. Over the past decade, the availability of axially chiral compounds has significantly improved through advancements in existing strategies and the introduction of modern catalytic atroposelective synthesis concepts. These synthetic advancements not only broaden the scope of chemical reactions, but also facilitate the construction of axially chiral frameworks with high application value. Currently, various synthetic methods are available for achieving stereoselective synthesis of axially chiral compounds under catalyst control, including desymmetrization, (dynamic) kinetic resolution, cross-coupling reactions, and de novo ring-forming synthesis. This paper focuses on recent advances in constructing atropisomers through palladium-catalyzed asymmetric cyclization strategies. Full article
(This article belongs to the Special Issue Recent Advances in Palladium-Catalyzed Organic Synthesis)
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26 pages, 6367 KiB  
Review
Advancements in Pd-Based Supported Porous Nanocatalysts for the C-C Cross-Coupling Reactions
by Debarati Chakraborty and Asim Bhaumik
Catalysts 2025, 15(1), 16; https://doi.org/10.3390/catal15010016 - 28 Dec 2024
Viewed by 1250
Abstract
Palladium (Pd) is a 4d transition metal with electronic configuration [Kr] 4d10 5s0, and it is one of the most widely studied metals in the periodic table due to its versatile catalytic role in organic synthesis. The choice [...] Read more.
Palladium (Pd) is a 4d transition metal with electronic configuration [Kr] 4d10 5s0, and it is one of the most widely studied metals in the periodic table due to its versatile catalytic role in organic synthesis. The choice of ligands that can coordinate with Pd sites plays a crucial role in the progress of the reaction. Due to the coexistence of multiple oxidation states (Pd(0)/Pd(II)), the active Pd sites of the catalysts can participate in various stages of the coupling reaction. The Pd-catalyzed C-C coupling reactions proceed through four steps: (1) oxidative addition of the reactant to the catalytic site, (2) transmetallation, (3) rearrangements of ligand centers and (4) reductive elimination to the coupling products. For the heterogeneous Pd nanocatalysts, active Pd sites are often strongly bound (chelated) with the solid catalyst surfaces. In this review, we have highlighted the advancements made in the heterogeneous Pd nanocatalysts with an emphasis on the types of different classes of porous solids, which could ligate with the Pd centers via strong covalent bonds. The high specific surface areas and small Pd sites of these nanocatalysts provide a larger number of catalytic sites and thus facilitate the reaction. Mechanistic aspects of the C-C cross-coupling reactions are discussed in the context of the structure–reactivity relationship. Full article
(This article belongs to the Special Issue Recent Advances in Palladium-Catalyzed Organic Synthesis)
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