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Advances in Neoadjuvant Therapy for Urologic Cancer

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: 30 June 2026 | Viewed by 2779

Editor


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Guest Editor
ARNAS Civico-Di Cristina-Benfratelli, P.Za Leotta Nicola, 4, 90127 Palermo, Italy
Interests: prostate cancer; renal cell carcinoma; urothelial cancer; germ cell tumor

Special Issue Information

Dear Colleagues,

In the last few decades, unprecedented improvements in the knowledge of the biology of genitourinary cancers have led to dramatic changes in the therapeutic landscape of these diseases.

Immune checkpoint inhibitors (ICIs) led to a paradigm shift in the treatment of genitourinary tumors, showing a significant improvement in survival outcomes. However, in other tumors, such as prostate and testis cancer, the role of ICIs remains marginal.

Recently, new targeted therapies, such as tyrosine kinase inhibitors (TKIs), antibody–drug conjugates (ADCs), and anti-FGFR drugs, are revolutionizing the treatment landscape of these tumors, and further studies are currently underway.

The present Special Issue aims to explore the implications of novel treatment strategies and biomarkers in neoadjuvant settings for patients suffering from genitourinary tumors.

Dr. Carlo Messina
Guest Editor

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • neoadjuvant treatment
  • bladder cancer
  • prostate cancer
  • renal cell carcinoma
  • penile cancers
  • immunotherapy
  • antibody–drug conjugates

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Published Papers (1 paper)

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Review

16 pages, 534 KB  
Review
The Management of Muscle Invasive Bladder Cancer: State of the Art and Future Perspectives
by Antonio Cigliola, Brigida Anna Maiorano, Doga Dengur, Valentina Tateo, Chiara Mercinelli, Michela Piacentini, Sara Inguglia, Carlo Messina and Andrea Necchi
Cancers 2025, 17(24), 4017; https://doi.org/10.3390/cancers17244017 - 17 Dec 2025
Viewed by 2290
Abstract
Background: Muscle-invasive bladder cancer (MIBC) represents a highly aggressive malignancy associated with significant morbidity and mortality. The current standard treatment, which includes radical cystectomy and platinum-based chemotherapy, is burdened by high toxicity and a substantial risk of relapse. For this reason, over the [...] Read more.
Background: Muscle-invasive bladder cancer (MIBC) represents a highly aggressive malignancy associated with significant morbidity and mortality. The current standard treatment, which includes radical cystectomy and platinum-based chemotherapy, is burdened by high toxicity and a substantial risk of relapse. For this reason, over the past decade, novel therapeutic strategies involving immune checkpoint inhibitors (ICIs), antibody–drug conjugates (ADCs), and targeted therapies have been investigated. This review aims to summarize current clinical evidence and ongoing trials evaluating these approaches in the perioperative setting. Methods: A systematic search was conducted using PubMed, EMBASE, and Cochrane databases, along with abstracts from major oncology conferences (ASCO, ESMO, SGO). Clinical trials assessing ICIs, ADCs, and targeted therapies, either alone or in combination with each other or with chemotherapy, in MIBC, were included. Results: Several early-phase and phase III trials have investigated the perioperative management of MIBC. Various studies evaluated the addition of ICIs to standard chemotherapy, demonstrating promising results in terms of pathological complete response. In parallel, the encouraging outcomes with ICIs and ADCs alone in the neoadjuvant or adjuvant setting paved the way for their combination in integrated strategies. Biomarker-driven approaches, based on circulating tumor DNA and specific genomic alterations, are being actively explored to improve patient selection and personalize treatment. Conclusions: ICIs, ADCs, and targeted therapies are reshaping the therapeutic landscape of MIBC. While early results are promising, further data and biomarker validation are essential to establish their definitive role and guide clinical decision-making in the perioperative setting. Full article
(This article belongs to the Special Issue Advances in Neoadjuvant Therapy for Urologic Cancer)
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