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Transforming Liver Cancer Care: From Molecular Understanding to Novel Therapeutic Strategies

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Tumor Microenvironment".

Deadline for manuscript submissions: 10 February 2026 | Viewed by 905

Special Issue Editor


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Guest Editor
Sanford School of Medicine, University of South Dakota, Sioux Falls, SD, USA
Interests: hepatology; gastroenterology; hepatocellular carcinoma; metabolic dysfunction-associated steatotic liver disease; alcohol-associated liver disease; liver transplantation

Special Issue Information

Dear Colleagues,

We are pleased to announce the call for submissions to a Special Issue of Cancers focusing on the theme of "Transforming Liver Cancer Care: From Molecular Understanding to Novel Therapeutic Strategies". Liver cancer, particularly hepatocellular carcinoma (HCC), remains a leading cause of cancer-related deaths worldwide. Advances in molecular research, biomarkers, and targeted therapies are transforming diagnosis and treatment. This Special Issue invites original research and reviews on the following:

  • Molecular and genetic mechanisms driving liver cancer.
  • Biomarkers for early detection, prognosis, and treatment response.
  • Innovations in targeted therapy, immunotherapy, and combination strategies.
  • Tumor microenvironment and therapeutic resistance.
  • Translational research bridging lab discoveries to clinical practice.

By showcasing emerging strategies, this collection aims to enhance liver cancer care and improve patient outcomes. We welcome your contributions.

Dr. Chencheng Xie
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • liver cancer
  • molecular research
  • biomarkers
  • targeted therapy
  • translational research

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Published Papers (1 paper)

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Review

31 pages, 1423 KB  
Review
Transforming Liver Cancer Therapy: Integrating Molecular Profiling with Precision and Transplant-Based Care
by Seoung Hoon Kim
Cancers 2025, 17(22), 3671; https://doi.org/10.3390/cancers17223671 - 16 Nov 2025
Viewed by 550
Abstract
Liver cancer, predominantly hepatocellular carcinoma (HCC), remains a leading cause of cancer-related mortality worldwide. Although systemic therapies have advanced in recent years, overall survival remains limited for many patients. A deeper understanding of the molecular and immunological landscape of HCC has driven the [...] Read more.
Liver cancer, predominantly hepatocellular carcinoma (HCC), remains a leading cause of cancer-related mortality worldwide. Although systemic therapies have advanced in recent years, overall survival remains limited for many patients. A deeper understanding of the molecular and immunological landscape of HCC has driven the emergence of new therapeutic paradigms, from molecularly targeted agents to immune checkpoint blockade. Concurrently, innovations in liver transplantation, liquid biopsy, and multi-omics profiling are reshaping the therapeutic algorithm for selected candidates. This review summarises recent progress in molecular classification, tumour microenvironment mapping, and immune modulation, and examines how these translational insights are redefining clinical practice. Particular emphasis is placed on the integration of molecular markers into transplant eligibility, downstaging strategies, and post-transplant immunosuppression, providing a comprehensive, precision-oriented framework that bridges basic discovery and patient-centred care. Full article
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