Molecular Mechanisms and Pathophysiology of Oral Cancer

Dear Colleagues,

Surgical resection is the first-line treatment for oral cancer; however, the quality of life of patients after surgical resection is significantly reduced. In recent years, molecular targeted drugs as well as immune checkpoint inhibitors have been developed for the treatment of oral cancer and have shown some efficacy against advanced oral cancer, but their effect is still not sufficient. In addition, the existence of the tumor microenvironment, consisting of tumor cells and tumor stroma, a heterogeneous cell population composed of various cell types, hinders our understanding of oral cancer progression and makes the development of oral cancer treatments difficult. In order to establish new therapeutic strategies, there is an urgent need to elucidate the molecular mechanisms and pathophysiology of oral cancer progression and metastasis, focusing on the tumor microenvironment. 

This Special Issue focuses on how the interaction between cancer cells and their microenvironment regulates the progression of oral cancer and contributes to the development, progression, and metastasis of oral cancer. This Special Issue solicits high-quality original papers and comprehensive review articles.

Dr. Kiyofumi Takabatake
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.