TP53 in Solid Tumors and Hematological Malignancies

Somatic mutations in the TP53 gene are one of the most frequent alterations in human cancers, mostly consisting of single-base substitutions distributed throughout the coding sequence, and are considered potential prognostic and predictive markers, as well as targets for pharmacological intervention.

In solid tumors and hematological malignancies, the frequency of TP53 mutations is relatively low compared to other tumors. Nevertheless, incidence increases in some cases with disease progression and is associated with a poor prognosis. Several therapeutic approaches have been tested or are currently in clinical development, aiming to target the TP53 pathway, either by blocking its interaction with MDM2 or by restoring the function of the altered protein. However, in TP53 mutated cases, an effective therapeutic option is still lacking.

This Special Issue will be focused on mechanisms of deregulation of TP53 and consequent prognostic impact in solid tumors and hematological malignancies, including acute and chronic leukemias, multiple myeloma, myelodisplastic syndromes and lymphomas, as well as the therapeutic options to interact with the TP53 pathway, highlighting future perspectives for improving treatment and cure rates in such aggressive diseases.

Dr. Cristina Papayannidis
Guest Editor

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