Special Issue "Tumor Microenvironment: A Key Piece in the Puzzle of Cancer Heterogeneity"
Deadline for manuscript submissions: closed (20 February 2023) | Viewed by 22503
Interests: therapy resistance; cancer metabolism; tumor microenvironment; acidosis; organoids; cancer-associated fibroblasts; precision medicine
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Cancers are now viewed as dynamic ecosystems in which subclonal populations of cancer cells and non-malignant cells within the tumor microenvironment (TME) interact cooperatively to support disease progression. Intratumoral heterogeneity has been extensively revealed in solid cancers through major advances in single-cell genomic and transcriptomic approaches. Besides genetic instability, the TME provides a strong selection pressure that shapes adaptive phenotypes in tumor cells and promotes resistance to therapy and higher metastatic potential, thereby sustaining malignant progression. Understanding the TME-related molecular mechanisms driving intratumor heterogeneity, evolution, therapy resistance, metastasis formation, and clinical relapse may allow new therapeutic avenues aiming to delay tumor progression to be identified.
For this Special Issue of Cancers, we invite authors to submit contributions that provide new insights into how TME contributes to cancer heterogeneity and tumor evolution. In particular, articles or review on new findings or concepts in the areas of metabolic plasticity, epigenetic regulation, tumor/stroma crosstalk, therapy resistance, immune escape and clinical relapse with respect to tumor evolution are of great interest.
Dr. Ivana Kurelac
Dr. Cyril Corbet
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- tumor microenvironment
- tumor heterogeneity
- drug resistance
- tumor evolution