Overview of Cancer Metabolism

Dear Colleagues,

Cancers are characterized by a high metabolic heterogeneity, allowing cancer cells to survive and proliferate in harsh microenvironmental conditions, including hypoxia, acidosis, and limited availability of metabolic resources. In recent years, a growing body of experimental and clinical evidence has been obtained, suggesting that the metabolic plasticity of malignant cells plays a key role in cancer progression. Indeed, metabolic activities of cancer cells directly influence (epi)genetic modifications, intra- and inter-cellular signaling, metastatic processes, immune escape, and response of tumors to different anticancer therapies. Recent technical developments have allowed us to reveal the spatially and temporally resolved complexity of the metabolic networks within tumors and their role in tumor initiation and progression.

The aim of this Topic is to present new reports that advance our knowledge on tumor metabolism. We welcome the submissions of original research articles and reviews that focus on all aspects of cancer cell metabolism, with a special focus on the interactions between cancer cells and their microenvironment, as well as on the alterations of the various hallmarks of cancer. Apart from the contributions of conference participants, manuscripts are welcome from other interested research groups. All manuscripts will be peer-reviewed.

Dr. Arnaud Blomme
Dr. Cyril Corbet
Topic Editors