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7.4
5.2
Journals
Cancers
Special Issues
Fertility Preservation in Oncology
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Fertility Preservation in Oncology

A special issue of Cancers (ISSN 2072-6694).

Deadline for manuscript submissions: closed (30 July 2023) | Viewed by 1103

Special Issue Editors

Dr. Giorgia Mangili

E-Mail Website
Guest Editor
Unit of Obstetrics and Gynaecology, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, 20132 Milan, Italy
Interests: gynecologic oncology; fertility preservation; chemotherapy
Special Issues, Collections and Topics in MDPI journals
Dr. Raffaella Cioffi

E-Mail Website
Guest Editor
Department of Gynaecological Oncology, San Raffaele Scientific Institute, 20132 Milan, Italy
Interests: gynecologic oncology; fertility preservation; chemotherapy

Special Issue Information

Dear Colleagues,

Over the past two decades, advances in oncological treatment have increased survival rates for most forms of cancer. This remarkable result entails a significant number of young women facing infertility in the future because of the gonadotoxic effects of chemotherapy and radiation.

Fertility preservation in oncology is a novel field of research that is becoming crucial in patient management, and is closely related to quality of life of cancer survivors.

This Special Issue aims to strengthen knowledge in the field of gonadal toxicity, focusing on mechanisms of damage and possible strategies for ovarian protection. It will also improve understanding around current and future fertility preservation strategies, i.e., oocyte and ovarian tissue cryopreservation, fertility-sparing surgery, and the use of ferto-protective agents.

In this Special Issue, original research articles and reviews are encouraged. Both pre-clinical and clinical studies will also be included.

We look forward to receiving your contributions.

Dr. Giorgia Mangili
Dr. Raffaella Cioffi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

 

Keywords

  • fertility preservation
  • oocyte cryopreservation
  • ovarian tissue cryopreservation
  • chemotherapy
  • radiotherapy
  • gonadotoxicity
  • gonadal protection
  • fertility sparing

Published Papers (1 paper)

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Research

9 pages, 243 KiB  
Article
Response to Controlled Ovarian Stimulation Is Not Impaired in Young Patients with a Sarcoma: Results from a Monocentric Case–Control Study
by Raffaella Cioffi, Luca Pagliardini, Antonio Quartucci, Enrico Papaleo, Valeria Stella Vanni, Salvatore Provenzano, Rossella Bertulli, Massimo Candiani and Giorgia Mangili
Cancers 2023, 15(12), 3141; https://doi.org/10.3390/cancers15123141 - 11 Jun 2023
Viewed by 870
Abstract
Sarcomas are relatively common in the young and their treatment can impair fertility. Fertility preservation can be achieved via the cryopreservation of gametes after controlled ovarian stimulation before cancer treatment. A reduced response to hormonal stimulation in patients suffering from certain types of [...] Read more.
Sarcomas are relatively common in the young and their treatment can impair fertility. Fertility preservation can be achieved via the cryopreservation of gametes after controlled ovarian stimulation before cancer treatment. A reduced response to hormonal stimulation in patients suffering from certain types of malignancy is reported. The purpose of this study was to assess the performance of oocyte cryopreservation in patients with sarcoma by comparing their outcomes with those of a population without cancer. Patients were matched by age with control women undergoing hormonal stimulation for isolated male factor infertility. The population included 84 women with a sarcoma and 355 controls. In the final analysis, 37 patients with sarcoma were matched in a 1:3 ratio with 109 healthy controls. Patients with sarcoma were generally younger and were stimulated with lower FSH doses. They did not perform worse than controls during stimulation, with an average retrieval of 10.6 oocytes vs. 8.1 in the controls. Linear regression on the number of retrieved mature oocytes confirmed that patients with sarcoma performed comparably to controls. In conclusion, patients with sarcoma can expect retrieval outcomes comparable to those of patients without cancer. Full article
(This article belongs to the Special Issue Fertility Preservation in Oncology)
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