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Cancers
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Clinicopathological Study of Gynecologic Cancer
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Clinicopathological Study of Gynecologic Cancer

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Clinical Research of Cancer".

Deadline for manuscript submissions: closed (30 June 2024) | Viewed by 4592

Special Issue Editor

Dr. Massimo Origoni

E-Mail Website
Guest Editor
Department of Gynecology & Obstetrics, Vita Salute San Raffaele University School of Medicine, IRCCS San Raffaele Scientific Institute, Via Olgettina 60, 20132 Milan, Italy
Interests: cervical cancer; human papillomavirus; HPV; gynecologic oncology; preventive oncology; CIN; cervical intraepithelial neoplasia
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Gynecological malignancies are a critical global challenge, as at present high mortality rates due to lack of early diagnosis are reported in many countries. In recent years, significant milestones have been achieved in terms of uncovering the biology and the natural history of neoplasms. For example, it is now known that understanding  the mechanisms of human papillomavirus can aid in the diagnosis and curing of different histological subtypes of cervical cancer. Additionally, genetic alterations play an important causal role in the development and progression of endometrial and ovarian cancers, and environmental factors, such as the genital microbiome, further exacerbate them. Given these findings, both biological and clinical research have increasingly focused on the identification and validation of biomolecular, pathological and omics parameters associated with the higher risk of cancer development in females; to an extent, such research has led to clinically relevant improvements in terms of persistence/recurrence rates and better survival rates. Therefore, in this Special Issue, we cordially invite submissions of original research and comprehensive review articles focusing on the promising results found in recent biological and clinical research which have the potential to improve clinical practice and patients’ treatment, thereby enhancing the management of female genital cancers.

Dr. Origoni Massimo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • gynecological oncology
  • gynaecological cancer
  • female cancer
  • uterine cancer
  • ovarian cancer
  • endometrial cancer
  • cancerogenesis
  • cancer biology
  • cell transformation
  • cancer pathology
  • cancer biology

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Published Papers (2 papers)

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Research

15 pages, 297 KiB  
Article
Enhancing Cervical Cancer Screening with 7-Type HPV mRNA E6/E7 Testing on Self-Collected Samples: Multicentric Insights from Mexico
by Carlos Eduardo Aranda Flores, Bente Marie Falang, Laura Gómez-Laguna, Guillermo Gómez Gutiérrez, Jorge Miguel Ortiz León, Miguel Uribe, Omar Cruz and Sveinung Wergeland Sørbye
Cancers 2024, 16(13), 2485; https://doi.org/10.3390/cancers16132485 - 8 Jul 2024
Cited by 1 | Viewed by 2002
Abstract
Cervical cancer remains a significant public health issue, particularly in regions with low screening uptake. This study evaluates the effectiveness of self-sampling and the 7-type HPV mRNA E6/E7 test in improving cervical cancer screening outcomes among a referral population in Mexico. A cohort [...] Read more.
Cervical cancer remains a significant public health issue, particularly in regions with low screening uptake. This study evaluates the effectiveness of self-sampling and the 7-type HPV mRNA E6/E7 test in improving cervical cancer screening outcomes among a referral population in Mexico. A cohort of 418 Mexican women aged 25 to 65, referred for colposcopy and biopsy due to abnormal cytology results (ASC-US+), participated in this study. Self-samples were analyzed using both the 14-type HPV DNA test and the 7-type HPV mRNA E6/E7 test. The study assessed the sensitivity, specificity, positive predictive value (PPV), and the necessity of colposcopies to detect CIN3+ lesions. Participant acceptability of self-sampling was also evaluated through a questionnaire. The 7-type HPV mRNA E6/E7 test demonstrated equivalent sensitivity but significantly higher specificity (77.0%) and PPV for CIN3+ detection compared to the 14-type HPV DNA test (specificity: 45.8%, p < 0.001). The use of the HPV mRNA test as a triage tool reduced the number of colposcopies needed per CIN3+ case detected from 16.6 to 7.6 (p < 0.001). Self-sampling was highly accepted among participants, with the majority reporting confidence in performing the procedure, minimal discomfort, and willingness to undertake self-sampling at home. Self-sampling combined with the 7-type HPV mRNA E6/E7 testing offers a promising strategy to enhance cervical cancer screening by improving accessibility and ensuring precise diagnostics. Implementing these app roaches could lead to a significant reduction in cervical cancer morbidity and mortality, especially in underserved populations. Future research should focus on the long-term impact of integrating these methods into national screening programs and explore the cost-effectiveness of widespread implementation. Full article
(This article belongs to the Special Issue Clinicopathological Study of Gynecologic Cancer)
16 pages, 566 KiB  
Article
Long-Term Follow-Up Outcomes in Women with In Situ/Microinvasive Adenocarcinoma of the Uterine Cervix Undergoing Conservative Treatment—Cervical Adenocarcinoma Study Group Italian Society of Colposcopy and Cervico-Vaginal Pathology
by Luca Giannella, Giovanni Delli Carpini, Jacopo Di Giuseppe, Camilla Grelloni, Giorgio Bogani, Marco Dri, Francesco Sopracordevole, Nicolò Clemente, Giorgio Giorda, Rosa De Vincenzo, Maria Teresa Evangelista, Barbara Gardella, Mattia Dominoni, Ermelinda Monti, Chiara Alessi, Lara Alessandrini, Angela Guerriero, Alessio Pagan, Marta Caretto, Alessandro Ghelardi, Andrea Amadori, Massimo Origoni, Maggiorino Barbero, Francesco Raspagliesi, Tommaso Simoncini, Paolo Vercellini, Arsenio Spinillo, Giovanni Scambia and Andrea Ciavattiniadd Show full author list remove Hide full author list
Cancers 2024, 16(6), 1241; https://doi.org/10.3390/cancers16061241 - 21 Mar 2024
Cited by 2 | Viewed by 2181
Abstract
Objective: The present study aimed to assess long-term follow-up outcomes in women with in situ/microinvasive adenocarcinoma (AC) of the uterine cervix treated conservatively. Methods: Retrospective multi-institutional study including women with early glandular lesions and 5-year follow-up undergoing fertility-sparing treatment. Independent variables associated with [...] Read more.
Objective: The present study aimed to assess long-term follow-up outcomes in women with in situ/microinvasive adenocarcinoma (AC) of the uterine cervix treated conservatively. Methods: Retrospective multi-institutional study including women with early glandular lesions and 5-year follow-up undergoing fertility-sparing treatment. Independent variables associated with recurrence were evaluated. Logistic regression analysis and Kaplan–Meier survival analysis with Logrank test were performed. Results: Of 269 women diagnosed with in situ/microinvasive AC, 127 participants underwent conservative treatment. During follow-up, recurrences were found in nine women (7.1%). The only factor associated with recurrence during follow-up was positive high-risk Human Papillomavirus (hr-HPV) testing (odds ratio 6.21, confidence interval 1.47–26.08, p = 0.012). HPV positivity in follow-up showed a recurrence rate of 21.7% against 3.8% in patients who were HPV-negative (p = 0.002, Logrank test). Among women with negative high-risk HPV tests in follow-up, recurrences occurred in 20.0% of non-usual-type histology vs. 2.1% of usual-type cases (p = 0.005). Conclusion: HPV testing in follow-up is of pivotal importance in women with early glandular lesions undergoing conservative treatment, given its recurrence predictive value. However, women who are high-risk HPV-negative in follow-up with non-usual-type histopathology may represent a sub-population at increased risk of recurrences. Further studies should confirm these findings. Full article
(This article belongs to the Special Issue Clinicopathological Study of Gynecologic Cancer)
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