Genomic Alterations in Leukemia (Volume II)
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Molecular Cancer Biology".
Deadline for manuscript submissions: closed (31 December 2024) | Viewed by 1476
Special Issue Editor
Interests: acute myeloid leukemia; acute lymphoblastic leukemia; genomics; functional modeling; targeted therapy; genome editing; single-cell sequencing
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Acute leukemias, including both acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML), are driven by constellations of genetic alterations with clinical, prognostic and therapeutic implications. The detection of these alterations and their associated transcriptional signatures is crucial for diagnosis, risk assessment and treatment. The dynamic and intricated heterogeneity of leukemic cells with the expansion of resistant clones may promote disease persistence or recurrence. Recently, the use of single-cell technologies has enabled us to dissect clonal heterogeneity, refine cell developmental state composition and explore interactions with the microenvironment, enhancing our understanding of acute leukemia pathogenesis and therapeutic responsiveness.
Rapid progress in genetic discovery has been accompanied by the growing development of faithful cellular and in vivo models, such as genetically engineered mice and xenografts of patient-derived cells in immune-deficient mice, which have elucidated the role of leukemia drivers and highlighted the importance of cellular origin.
Moreover, recent advances in computational analysis methods and machine learning models offer opportunities to advance diagnosis, predict prognosis, and guide therapy.
This Special Issue will highlight the current state of the art in both ALL and AML and discuss future perspectives to improve the analysis of acute leukemia at both bulk and single-cell resolution and advance clinical management and therapeutic approaches.
Dr. Ilaria Iacobucci
Guest Editor
Manuscript Submission Information
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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.
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Keywords
- acute leukemia
- functional genomics
- classification
- single cells
- germline predisposition
- mouse models
- genome editing
- machine learning
- therapeutic targeting
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