Mediastinal and Central Nervous System Germ Cell Tumors

Dear Colleagues, 

The Special Issue is on mediastinal and central nervous system germ cell tumors. These are very rare diseases which are related to testicular germ cell tumors in terms of histology, cytogenetic abnormalities, and marker production.

Nevertheless, these diseases have unique characteristics in terms of origin (which is still debated today), prognosis, and, for some aspects, therapeutic strategies. As they are rare germ cell tumors (around 1–2% of all germ cell cancers) we think that an educational comprehensive review on the topic may be helpful. We also would like to share with you the most important results from major institutions along with clinical, pathologic, biologic features. Compared to testicular counterpart, we are still lacking good results obtained in these diseases. Much work is ahead of us.

This Special Issue will contain updated information regarding these peculiar diseases. These are rare tumors close to the testicular counterpart, but with some specific aspects, that is to say, severe prognosis, unknown origin, and particular therapeutic aspects. We will try to summarize the best available knowledge in this field. Contributions from different major institutions with be reported, together with new drugs and clinical aspects.

Dr. Giovanni Rosti
Prof. Dr. Paolo Pedrazzoli
Dr. Ugo De Giorgi
Guest Editors

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