Special Issue "New Insights into the Molecular Mechanism of Epithelial Plasticity in Cancer"
Deadline for manuscript submissions: 15 September 2022 | Viewed by 2896
Interests: Cancer, Epithelial plasticity, Metastasis, Drug resistance, Small-molecule inhibitors, E3 ubiquitin-ligase, Targeted therapy
Epithelial cell plasticity is a reversible program that refers to the ability of epithelial cells to dynamically switch between different phenotypic cellular states. This program has been highlighted during the epithelial-to-mesenchymal transition (EMT) in tumour progression and metastasis. Tumour cells undergo EMT loose cell-cell and cell-extracellular matrix interactions, leading to cell migration and invasion. It has become evident that transcriptional, post-transcriptional, and post-translational events are critical regulators of the EMT. Moreover, in recent years, EMT has been associated to stemness and therapy resistance, critically representing one of the major challenges in oncology. Indeed, EMT has been proposed as a good therapeutic target for the designing of novel strategies against cancer.
In this Special Issue, we focus on new molecular mechanisms implicated by the epithelial plasticity in cancer and novel therapeutic strategies against EMT to overcome drug resistance and metastasis.
Dr. Angélica Figueroa
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Epithelial plasticity
- Drug resistance
- Target therapy