Mechanisms of Cancer Cells Escape from Immune Surveillance: The Focus on Epigenetic and Pro-inflammatory Adaptations
A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Immunology and Immunotherapy".
Deadline for manuscript submissions: closed (30 September 2024) | Viewed by 3507
Special Issue Editors
Interests: breast cancer; esophageal adenocarcinoma; hepatocellular carcinoma; estrogen receptors; sphingolipids; cancer stem cells; immune evasion; cytokine storm
Special Issues, Collections and Topics in MDPI journals
Interests: brain cancer; glycolysis; abnormal tumor metabolism; tumor biomarkers; apoptosis; chemotherapy; multitarget anticancer agents
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Anti-cancer surveillance is one of the most important functions of the immune system as it helps to eliminate transformed and malfunctioning cells. However, many cancer cells manage to hide from the screening for elimination and/or survive the immune defense mechanisms. Cancer cell survival results in the development of resistance, metastasis, and cancer recurrence. The development of cancer resistance is a multifactorial and largely unclear process that is orchestrated by various signaling mechanisms, including growth-promoting and anti-apoptotic gene activation. Epigenetic factors and the tumor microenvironment are often involved in the regulation of carcinogenesis and development of chemo- and radiotherapy resistance. Elevated and/or disbalanced levels of pro-inflammatory molecules may often contribute to the development of resistance and promote the cancer progression toward a more aggressive phenotype, which is associated with high cancer morbidity and mortality. This Special Issue of Cancers presents current advances in the understanding of molecular mechanisms of cancer cell escape from immune surveillance and development of cancer chemo- and radio-resistance. The Issue is also focused on the description of novel anticancer methodologies that target epigenetic gene regulation and the pro-inflammatory tumor microenvironment. Original research manuscripts, insightful reviews, and idea-provoking letters that discuss novel mechanisms of cancer cells' adaptations to immune surveillance, survival, and resistance are invited.
Dr. Olga Sukocheva
Dr. Margarita Neganova
Guest Editors
Manuscript Submission Information
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Keywords
- immune surveillance
- cancer resistance
- tumor microenvironment
- cancer immunoediting
- epigenetic regulation
- apoptosis
- necroptosis
- cuproptosis
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