Special Issue "Inflammation and Cancer Metastasis"

A special issue of Cancers (ISSN 2072-6694).

Deadline for manuscript submissions: closed (15 March 2019)

Special Issue Editor

Guest Editor
Prof. Dr. Masakiyo Sakaguchi

Department of Cell Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700-8558, Japan
Website | E-Mail
Interests: cancer metastasis, inflammation, molecular based cell signaling, advanced therapeutic approaches

Special Issue Information

Dear Colleagues,

Cancer metastasis is the most serious problem in cancer patients because of its life-threatening nature owing to multiple organ dysfunctions caused by the growth of disseminated cancer. To overcome the problem of the metastasis dimension of cancer cells, a mechanistic understanding of cancer metastasis is necessary. The ‘seed and soil’ theory that was first proposed by Paget et al. (Cancer Metastasis Rev 1989) may become a critical clue for obtaining a partial understanding of the complex mechanism of cancer distant metastasis. The ‘seed’ represents cancer cells and ‘soil’ represents the cancer favorite organ for the destination of metastasis. Now, we have well documented that inflammation is the key event to raising the cancer-mediated soil field, termed the pre-metastatic niche, in distant organs. Soil also provides an immune suppressive environment so that cancers that arrive in certain soils readily initiate their growth again. Inflammation is expected to occur in not only distant pre-metastatic organs but also in cancer surrounding microenvironments at their primarily developed sites. Inflammation triggered by the primary cancer site provides cancer cells with a driving force of micro-metastasis with invasion, which causes them to travel towards their favorite distant organs more quickly. In this inflammation-mediated metastasis, multiple processes with a variety of signal mechanisms that require a large number of molecules are mutually contributed. Such intracellular and extracellular mechanisms are exerted in the field, including not only cancer cells but also multiple normal cells.

In this Special Issue, we aim to compile critical insights on the mutual relationship between inflammation and cancer metastasis; accordingly, we welcome articles on basic, preclinical, and clinical research related to this this theme. We hope that the collected results will be helpful for gaining an understanding of dimensions of cancer-mediated inflammation that require a prerequisite of metastatic malignancy and for establishing a preclinical rationale to target a newly identified axis in order to further improve clinical responses and patient survival.

Prof. Dr. Masakiyo Sakaguchi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • metastasis
  • soil and seed theory
  • inflammation
  • cancer microenvironment
  • cancer stroma
  • cancer stem cells
  • circulating cancer cells
  • epithelial and mesenchymal transition (EMT)
  • immune suppression
  • damage-associated molecular patterns (DAMPs)
  • cytokines
  • chemokines
  • growth factors

Published Papers

There is no accepted submissions to this special issue at this moment.
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