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Macrophages in Colorectal Cancer Liver Metastases

Department of Immunology and Inflammation, Humanitas Clinical and Research Center, 20089 Rozzano, Italy
Department of Hepatobiliary and General Surgery, Humanitas Clinical and Research Center, 20089 Rozzano, Italy
Department of Biotechnology and Translational Medicine, University of Milan, 20090 Segrate, Italy
Department of Biomedical Science, Humanitas University, 20089 Rozzano, Italy
Author to whom correspondence should be addressed.
Cancers 2019, 11(5), 633;
Received: 30 March 2019 / Revised: 2 May 2019 / Accepted: 3 May 2019 / Published: 7 May 2019
(This article belongs to the Special Issue Inflammation and Cancer Metastasis)
PDF [925 KB, uploaded 7 May 2019]


Tumor-associated macrophages (TAMs) provide a nurturing microenvironment for metastasis and are concomitantly key determinants of the efficacy of anticancer strategies. TAM represent an extremely heterogeneous population in terms of cell morphology, functions, and tissue localization. Colorectal liver metastases (CLM) display a high heterogeneity, responsible for a wide array of clinical presentations and responsiveness to treatments. In the era of precision medicine, there is a critical need of reliable prognostic markers to improve patient stratification, and, for their predominance in metastatic tissues, TAMs are emerging as promising candidates. View Full-Text
Keywords: macrophages; colorectal liver metastases; immune landscape macrophages; colorectal liver metastases; immune landscape

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Cortese, N.; Soldani, C.; Franceschini, B.; Barbagallo, M.; Marchesi, F.; Torzilli, G.; Donadon, M. Macrophages in Colorectal Cancer Liver Metastases. Cancers 2019, 11, 633.

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