Breast-Conserving Therapy for Breast Cancer

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: closed (30 April 2024) | Viewed by 2361

Special Issue Editor


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Guest Editor
Breast Unit, AOU of Sassari, 07100 Sassari, Italy
Interests: breast cancer; breast conserving treatment; mastectomy; radiotherapy; neoadjuvant treatment
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Special Issue Information

Dear Colleagues,

The modern management of breast cancer consists of a multidisciplinary approach, including systemic and locoregional treatments. Considerable advances have been made in the surgical treatment, with the development of new techniques that have improved the aesthetic outcomes in patients submitted to breast-conserving surgery or mastectomy. Nonetheless, breast conservation should be the preferred choice when technically feasible, since it is linked to better outcomes in terms of quality of life, cosmetic satisfaction, and psychological well-being when compared to mastectomy with immediate or delayed reconstruction. More importantly, recent large studies enlightened that patients undergoing breast-conserving surgery plus radiation therapy may have better survival outcomes than those who undergo mastectomy.

In this Special Issue, original research articles and reviews are welcome that address the topic of breast conservation in the multidisciplinary management of breast cancer. The main goal is to highlight the new insights that have emerged in breast- conservative treatment in relation to recent clinical, biological and epidemiological studies on breast cancer.    

Research areas may include (but are not limited to) the following:

  • Survival advantages of breast-conserving therapy over mastectomy.
  • Advances in external radiotherapy after breast conservation surgery.
  • Systemic effects of radiation therapy in patients undergoing breast conservative surgery.
  • Intraoperative radiotherapy (IORT)
  • Intraoperative localization of nonpalpable breast cancers.
  • Oncoplastic surgery in patients receiving breast conservation.
  • Trends in mastectomy and breast-conserving surgery in different world regions.
  • Interactions between immune system and surgical trauma.
  • Psychological benefits of breast conservation in patients with breast cancer.
  • Breast-conserving surgery in young patients with breast cancer.
  • Breast-conserving surgery in luminal breast cancer.
  • Breast-conserving surgery in triple-negative and HER2-positive breast cancer.
  • Redo breast-conserving surgery in patients with locoregional recurrence.
  • Breast-conserving surgery in patients with multifocal/multicentric disease.
  • Breast-conserving surgery after neoadjuvant chemotherapy.
  • Breast-conserving surgery in the prophylactic or curative treatment in germline mutation carriers.
  • Role of multidisciplinary team in the decision-making process of surgical treatment.

I look forward to receiving your contributions.

Dr. Alessandro Fancellu
Guest Editor

Manuscript Submission Information

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Keywords

  • breast-conserving therapy
  • mastectomy
  • survival outcomes
  • radiotherapy
  • oncoplastic surgery
  • chemotherapy
  • molecular subtypes

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Published Papers (1 paper)

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Research

11 pages, 1031 KiB  
Article
Neoadjuvant Chemotherapy in Breast Cancer: Evaluation of the Impact on Surgical Outcomes and Prognosis
by Corrado Chiappa, Maltecca Greta, Leoni Miriam, Giuseppe Ietto, Davide Inversini, Andrea Ballabio, Alice Bonetti, Alberto Mangano, Rossana Gueli, Giulio Carcano and Francesca Angela Rovera
Cancers 2024, 16(13), 2332; https://doi.org/10.3390/cancers16132332 - 26 Jun 2024
Cited by 2 | Viewed by 1985
Abstract
The correlation between TNM staging and histology variations in a sample of patients who underwent neoadjuvant chemotherapy demonstrates a positive impact on both increasing conservative surgery and achieving pCR, resulting in better outcomes in terms of disease-free survival (DFS) and the risk of [...] Read more.
The correlation between TNM staging and histology variations in a sample of patients who underwent neoadjuvant chemotherapy demonstrates a positive impact on both increasing conservative surgery and achieving pCR, resulting in better outcomes in terms of disease-free survival (DFS) and the risk of relapse. Benefits have also been highlighted in terms of cosmetic outcomes, postoperative complications, and psychological benefits. However, the overall outcomes must be evaluated according to the subtype and individual characteristics of the patients. Full article
(This article belongs to the Special Issue Breast-Conserving Therapy for Breast Cancer)
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