Special Issue "Hedgehog Signaling in Cancer"

A special issue of Cancers (ISSN 2072-6694).

Deadline for manuscript submissions: 30 June 2019

Special Issue Editors

Guest Editor
Prof. Dr. Francisco Vega

Professor and Director of the Division of Hematopathology, Department of Pathology and Laboratory Medicine, Medical Director of the Biospecimen Shared Resource, University of Miami/Sylvester Comprehensive Cancer Center, Miami. Florida, USA
Website | E-Mail
Interests: lymphomas; diffuse large cell lymphoma; chemoresistance in lymphomas; hedgehog signaling; smoothened
Guest Editor
Dr. Ralf Landgraf

Cancer Biology Graduate Program, University of Miami, Miller School of Medicine, Box 016129 (R-629) Miami, Florida, USA
Website | E-Mail
Interests: receptor signaling in cancer; breast cancer; protein kinases; membrane micro environment; molecular interactions; smoothened

Special Issue Information

Dear Colleagues,

The hedgehog (Hh) signaling pathway is a highly regulated pathway that is important, not only for embryonic development, tissue patterning, and organogenesis, but also for tissue repair and the maintenance of stem cells in adult tissues. Emerging data demonstrate abnormal activation of the Hh signaling components in multiple cancers providing proliferative and survival roles, contributing to maintenance of the cancer stem cell compartment and enhancing tolerance or resistance to chemotherapeutic agents.

The key signal transmission component of Hh signaling is the seven-transmembrane-spanning protein Smoothened (SMO). There is growing evidence supporting that SMO does not act as a mere signal transducer for Hh but may also serve to enhance the activation of several membrane based signaling with importance in cancer biology. SMO signaling is best studied in cilia, a highly specialized surface organelle with a role in developmental signaling. However, loss of cilia assembly has minor phenotypes compared to the loss of SMO signaling components. More importantly, cilia are absent in most cancer cells and still SMO is highly expressed and functional.

In this Special Issue, we would like to focus in these novel potential non-canonical functions of SMO that seems to be relevant in cancer pathobiology. We expect to recollect novel information in the field, that will help us to improve the understanding of this interesting molecule and its cellular role in cancer.

Prof. Dr. Francisco Vega
Dr. Ralf Landgraf
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Smoothened
  • non-canonical hedgehog
  • lymphomas
  • cancer
  • chemoresistance
  • cholesterol
  • patched

Published Papers

This special issue is now open for submission.
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