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Healthcare
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Active Care for Patients with Endometrial Carcinoma
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Active Care for Patients with Endometrial Carcinoma

A special issue of Healthcare (ISSN 2227-9032). This special issue belongs to the section "Women's Health Care".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 1194

Special Issue Editor

Dr. Carlo Ronsini

E-Mail Website
Guest Editor
Department of Woman, Child and General and Specialized Surgery, University of Campania “Luigi Vanvitelli”, 81100 Caserta, CE, Italy
Interests: gynecologic oncology; surgical gynecology; biomarkers; endometrial carcinoma; ovarian carcinoma; cervical carcinoma
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are pleased to invite you to collaborate on this Special Issue focused on endometrial cancer. Recently, the FIGO association has updated the Staging of Endometrial Carcinoma to give a better prognostic contextualisation to various elements that have shown a great clinical impact such as histotype, grading, lymphovascular and myometrial space invasion, and microsatellite instability. This ushered in an era of great scientific revolution, with a broadening of our horizons and the possibility of moving into new, unexplored fields.

This Special Issue aims to collect the latest scientific evidence on the topic and optimising current clinical diagnostic and therapeutic practices in standard care and oncofertility. At the same time, it wants to collect all the study hypotheses capable of personalising treatment for endometrial carcinomas.

Researchers are invited to contribute with novel original trials, reviews and meta-analyses, to raise awareness on endometrial cancer. We invite oncologists, gynaecologists, biologists, nurses, psychologists and researchers in related fields to contribute their robust scientific manuscripts.

I look forward to receiving your contributions.

Dr. Carlo Ronsini
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Healthcare is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • endometrial cancer
  • microsatellite instability
  • immunotherapy
  • gynaecological surgery
  • fertility sparing
  • palliative care

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Published Papers (1 paper)

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9 pages, 438 KiB  
Systematic Review
Now or Later? The Role of Neoadjuvant Treatment in Advanced Endometrial Cancer: A Systematic Review
by Carlo Ronsini, Irene Iavarone, Alessandro Carotenuto, Antonio Raffone, Giada Andreoli, Stefania Napolitano, Pasquale De Franciscis, Domenico Ambrosio and Luigi Cobellis
Healthcare 2024, 12(23), 2404; https://doi.org/10.3390/healthcare12232404 - 29 Nov 2024
Viewed by 951
Abstract
Background: Endometrial cancer (EC) is, nowadays, the most frequent gynecological malignancy worldwide. The main treatment approach for EC is surgery, especially for early-stage tumors. For advanced EC, chemotherapy (CT) with carboplatin and paclitaxel is the standard treatment, especially for women with metastatic or [...] Read more.
Background: Endometrial cancer (EC) is, nowadays, the most frequent gynecological malignancy worldwide. The main treatment approach for EC is surgery, especially for early-stage tumors. For advanced EC, chemotherapy (CT) with carboplatin and paclitaxel is the standard treatment, especially for women with metastatic or recurrent disease. The present systematic review aimed to establish whether neoadjuvant treatment regimens with CT and/or radiotherapy (RT) lead to better survival outcomes compared to upfront surgery in advanced EC. Methods: Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement, through the string “((“Endometrial Neoplasms”[Mesh]) AND “Hysterectomy”[Mesh]) AND “Radiotherapy”[Mesh] AND Chemotherapy”, the selection of articles was made. A quality assessment was conducted using the Newcastle–Ottawa Scale (NOS). The studies included patients with EC with survival and recurrence outcomes—patients treated with upfront surgery or neoadjuvant CT ± External Beam Radiation Therapy (EBRT) or CT ± Brachytherapy (BT). Results: According to the selected evidence in the scientific literature, the 5-year DFS was 21.3% for upfront surgery and ranged from 42 to 73% for neoadjuvant chemotherapy. Also, the 5-year OS was 6.2 to 49.7% with upfront surgery and 15.5 to 100% for neoadjuvant schemes. None of the studies dedicated to surgery reported the 5-year Recurrence Rate (RR), while in the neoadjuvant treatments, it ranged from 27 to 64.7%. Conclusions: The literature’s paucity of data makes it difficult to compare neoadjuvant therapy regimens with upfront surgery in advanced endometrial carcinoma. Nevertheless, the current data show more encouraging results for the neoadjuvant treatment group. Full article
(This article belongs to the Special Issue Active Care for Patients with Endometrial Carcinoma)
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