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Cancers
Special Issues
Fertility Issues in Cancer Survivors
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Fertility Issues in Cancer Survivors

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Survivorship and Quality of Life".

Deadline for manuscript submissions: closed (5 September 2024) | Viewed by 3595

Special Issue Editor

Dr. Eleonora Porcu

E-Mail Website
Guest Editor
Department of Medical and Surgical Sciences, Alma Mater Studiorum Università di Bologna, Bologna, Italy
Interests: fertility preservation; ovulation induction; vitrification; infertility

Special Issue Information

Dear Colleagues,

Following advances in cancer therapy, the majority of adolescents or young adults will become long-term cancer survivors. Young cancer survivors experience a higher risk of infertility than the general population, but individual risk is highly variable depending on cancer type and type and dose of antineoplastic therapy. Fertility loss can be a devastating consequence of cancer treatment for survivors, resulting in poorer quality of life. Prior studies have shown that potential loss of fertility can be as painful as the cancer diagnosis itself, and for some, the possibility of preserving fertility is fundamental to coping with the burden of cancer treatment. Thus, it is mandatory to carry out a fertility consultation before starting antineoplastic treatments.

Fertility counseling before cancer treatment aims to inform patients and families about their future fertility potential and to facilitate the preservation of fertility. The purpose of this Special Issue is to improve knowledge on the gonadotoxicity of oncological and radiotherapy treatments in order to choose and customize the most suitable fertility preservation techniques for men and women.

Furthermore, this collection aims to evaluate the outcomes of spontaneous pregnancies and from in vitro fertilization techniques arising in cancer survivors and perinatal and pediatric follow-up of the births in order to compare them with the general population.

Dr. Eleonora Porcu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • oncofertility
  • oocyte cryopreservation
  • sperm cryopreservation
  • fertility
  • reproductive health
  • child development

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Published Papers (2 papers)

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12 pages, 2051 KiB  
Article
Fertility Preservation in More than 7000 Male Patients: A Single-Center, Tertiary Care Registry Study over 30 Years
by Andrea Graziani, Giuseppe Grande, Michel Martin, Donatella Sorio, Federica Finocchi, Sara Corrò, Nicola Passerin, Adriano Presciutti, Antonella Di Mambro, Riccardo Selice, Andrea Garolla and Alberto Ferlin
Cancers 2025, 17(4), 689; https://doi.org/10.3390/cancers17040689 - 18 Feb 2025
Viewed by 402
Abstract
Background/Objectives: Semen cryopreservation has been widely used in recent decades, mainly in patients with male factor infertility (MFI) and patients with cancer (to preserve their fertility potential before undergoing gonadotoxic treatments, such as chemotherapy or radiotherapy). Methods: we evaluated the temporal [...] Read more.
Background/Objectives: Semen cryopreservation has been widely used in recent decades, mainly in patients with male factor infertility (MFI) and patients with cancer (to preserve their fertility potential before undergoing gonadotoxic treatments, such as chemotherapy or radiotherapy). Methods: we evaluated the temporal trend and the existence of factors determining the usage of cryopreserved semen (in order, for instance, to conceive using assisted reproduction techniques (ARTs)). We evaluated 7044 patients who cryopreserved since 1991, evaluating clinical information such as the diagnosis, age, the method with which the collection took place and the number of pick-ups for use in ART. Results: The mean age of the patients was 33.12 ± 8.41 years. The most common cancers were testicular (1758/3262) and hematological cancers (942/3262). Patients who underwent cryopreservation for MFI picked up their samples much more than neoplastic patients (42.15% vs. 8.55%). Patients 35–40 years old picked up their samples more frequently when compared with other age groups. Moreover, we found several data regarding the sub-types of cancers and the methods of semen collection. Conclusions: According to our results, the indication for semen cryopreservation, age and the method of collection might represent a simple way to predict the future use of semen for ART. Full article
(This article belongs to the Special Issue Fertility Issues in Cancer Survivors)
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Review

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16 pages, 681 KiB  
Review
Immune Checkpoint Inhibitors and Male Fertility: Should Fertility Preservation Options Be Considered before Treatment?
by Elissavet Ntemou, Emily Delgouffe and Ellen Goossens
Cancers 2024, 16(6), 1176; https://doi.org/10.3390/cancers16061176 - 17 Mar 2024
Cited by 1 | Viewed by 2578
Abstract
In recent years, immune checkpoint inhibitors (ICIs) have become a viable option for many cancer patients, including specific subgroups of pediatric patients. Despite their efficiency in treating different types of cancer, ICIs are responsible for a number of immune-related adverse events, including inflammatory [...] Read more.
In recent years, immune checkpoint inhibitors (ICIs) have become a viable option for many cancer patients, including specific subgroups of pediatric patients. Despite their efficiency in treating different types of cancer, ICIs are responsible for a number of immune-related adverse events, including inflammatory toxicities, that can affect several organs. However, our knowledge of the impact of ICIs on the testis and male fertility is limited. It is possible that ICI treatment affects testicular function and spermatogenesis either directly or indirectly (or both). Treatment with ICIs may cause increased inflammation and immune cell infiltration within the seminiferous tubules of the testis, disturbing spermatogenesis or testosterone deficiency (primary hypogonadism). Additionally, the interference of ICIs with the hypothalamic–pituitary–gonadal axis may alter testosterone production, affecting testicular function (secondary hypogonadism) and spermatogenesis. This review provides an overview of the available evidence on the potential association between ICIs and the disruption of spermatogenesis, with special focus on ICIs targeting cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), programmed death protein 1 (PD-1) and programmed death-ligand 1 (PD-L1). Moreover, it highlights the need for further investigations and encourages the discussion of associated risks and fertility-preservation considerations between clinicians and patients. Full article
(This article belongs to the Special Issue Fertility Issues in Cancer Survivors)
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