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MicroRNA (miRNA) in Cancers

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Molecular Cancer Biology".

Deadline for manuscript submissions: closed (31 October 2025) | Viewed by 1383

Special Issue Editors


E-Mail Website
Guest Editor
Department of Gynecology and Obstetrics, University Hospital Aachen, 52074 Aachen, Germany
Interests: miRNAs; cancer; personalized medicine
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Gynecology and Obstetrics, University Hospital Aachen, 52074 Aachen, Germany
Interests: miRNAs; cancer

Special Issue Information

Dear Colleagues,

MicroRNAs (miRNAs) are small, non-coding RNA molecules that play a crucial role in regulating gene expression. In cancer, miRNAs function as both tumor suppressors and oncogenes, influencing cancer development, progression, and metastasis. Aberrant miRNA expression can lead to the dysregulation of critical pathways involved in cell proliferation, apoptosis, and differentiation. Recent research highlights the potential of miRNAs as diagnostic biomarkers and therapeutic targets. As our understanding of miRNA biology deepens, their integration into clinical practice offers promising avenues for improving cancer diagnosis, treatment, and patient outcomes. We invite you to contribute to the burgeoning field of microRNAs (miRNAs) in cancer research and to publish in this Special Issue innovative studies that deepen our understanding of miRNA biology and explore their clinical applications. Your research could pave the way for novel diagnostic tools and therapeutic strategies, transforming the realm of personalized medicine. Join us in this exciting endeavor to harness the power of miRNAs for improving cancer diagnosis, treatment, and patient outcomes.

Dr. Jochen Maurer
Prof. Dr. Elmar Stickeler
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • miRNAs
  • cancer
  • diagnostics
  • tumor progression
  • metastasis
  • therapeutic targets
  • personalized medicine
  • pathways

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Published Papers (1 paper)

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Research

18 pages, 4365 KB  
Article
Stage-Specific miRNA Profiling Reveals Key Regulators of EMT and EGFR-TKI Resistance in Gallbladder Cancer
by Neeraj Saklani, Puja Sakhuja, Surbhi Goyal, Anil Kumar Agarwal, Sarangadhara Appala Raju Bagadi and Poonam Gautam
Cancers 2026, 18(3), 502; https://doi.org/10.3390/cancers18030502 - 3 Feb 2026
Viewed by 747
Abstract
Background: Gallbladder cancer (GBC) is a highly aggressive malignancy characterized by a poor prognosis, particularly in its advanced stages. While microRNAs (miRNAs) regulate cancer progression, their specific role in the transition from early to advanced GBC is poorly understood. Methods: We performed miRNA [...] Read more.
Background: Gallbladder cancer (GBC) is a highly aggressive malignancy characterized by a poor prognosis, particularly in its advanced stages. While microRNAs (miRNAs) regulate cancer progression, their specific role in the transition from early to advanced GBC is poorly understood. Methods: We performed miRNA expression profiling on 41 formalin-fixed paraffin-embedded (FFPE) tissues, including 10 gallstone disease (GSD) controls, 14 early-stage GBC (stage I and II), and 17 advanced-stage GBC cases (stage III and IV), using the NanoString nCounter platform. Differentially expressed miRNAs (DEMs) were identified followed by miRNA target identification using miRTarBase. Results: We identified 43 significantly dysregulated miRNAs in early-stage and 46 in advanced-stage GBC compared to controls. Based on the literature search, we found EMT-inhibiting miRNAs (miR-200 family) to be overexpressed in early stage and downregulated in advanced stages (miR-574-3p, miR-195-5p) in our study. Pathway analysis revealed significant enrichment of the ‘EGFR tyrosine kinase inhibitor resistance’ pathway in both the stages. The correlation of DEMs with clinicopathological features revealed that the expression of miR-361-3p and miR-423-5p was significantly associated with tumor grade (r = −0.605, p = 0.0003) and lymph node status (r = −0.621, p = 0.0001), respectively. Conclusions: This study identifies distinct miRNA signatures associated with GBC initiation and progression, offering insights into the molecular pathogenesis of the disease. Furthermore, functional studies of the miRNAs implicated in EMT and EGFR-TKI resistance may be conducted using GBC cell lines to dissect the precise roles of key miRNAs and explore their potential as novel therapeutic targets in GBC. Full article
(This article belongs to the Special Issue MicroRNA (miRNA) in Cancers)
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