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Advances in the Diagnosis and Treatment of Prostate Cancer: From...
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Advances in the Diagnosis and Treatment of Prostate Cancer: From Biomarkers to Precision Surgery

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: 30 May 2026 | Viewed by 741

Special Issue Editors

Dr. Stamatios N. Katsimperis

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Guest Editor
2nd Department of Urology Sismanoglio General Hospital, University of Athens, Athens, Greece
Interests: urology
Dr. Lazaros Tzelves

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Guest Editor
2nd Department of Urology, National and Kapodistrian University of Athens, Sismanogleion Hospital, 11526 Athens, Greece
Interests: urolithiasis; robotic surgery; prostate cancer; kidney cancer; bladder cancer
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

This Special Issue will focus on recent innovations and clinical advances in prostate cancer, spanning early detection, risk stratification, novel imaging modalities, minimally invasive and robotic surgical techniques, and the integration of molecular biomarkers into personalized treatment strategies. Emphasis will be placed on multidisciplinary approaches and the evolving role of artificial intelligence and genomics in clinical decision making.

For this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following:

  • Prostate cancer;
  • Precision medicine;
  • Molecular biomarkers;
  • Risk stratification;
  • Robotic surgery;
  • Artificial intelligence;
  • Genomics;
  • Personalized treatment;
  • Imaging modalities;
  • Multidisciplinary approach.

We look forward to receiving your contributions.

Dr. Stamatios N. Katsimperis
Dr. Lazaros Tzelves
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • prostate cancer
  • precision medicine
  • molecular biomarkers
  • risk stratification
  • robotic surgery
  • artificial intelligence
  • genomics
  • personalized treatment
  • imaging modalities
  • multidisciplinary approach

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Published Papers (1 paper)

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12 pages, 808 KB  
Systematic Review
Radical Prostatectomy Following Holmium Laser Enucleation of the Prostate (HoLEP): A Systematic Review of Perioperative, Oncological, and Functional Outcomes
by Stamatios Katsimperis, Lazaros Tzelves, Titos Markopoulos, Themistoklis Bellos, Konstantinos Douroumis, Nikolaos Kostakopoulos and Andreas Skolarikos
Cancers 2025, 17(22), 3685; https://doi.org/10.3390/cancers17223685 - 18 Nov 2025
Viewed by 527
Abstract
Background: The widespread adoption of holmium laser enucleation of the prostate (HoLEP) has led to a growing number of men subsequently diagnosed with localized prostate cancer requiring radical prostatectomy (RP). However, anatomical alterations after HoLEP may increase surgical complexity and affect outcomes. [...] Read more.
Background: The widespread adoption of holmium laser enucleation of the prostate (HoLEP) has led to a growing number of men subsequently diagnosed with localized prostate cancer requiring radical prostatectomy (RP). However, anatomical alterations after HoLEP may increase surgical complexity and affect outcomes. This systematic review aimed to synthesize current evidence on perioperative, oncological, and functional outcomes of RP following HoLEP. Methods: A systematic literature search was conducted in PubMed, CENTRAL, and ClinicalTrials.gov through to September 2025 in accordance with PRISMA 2020 guidelines (PROSPERO CRD420251134483). Eligible studies included patients undergoing RP after HoLEP with reported perioperative, oncologic, or functional data. Methodological quality was assessed using the ROBINS-I tool, and results were synthesized narratively. Results: Eight retrospective studies comprising 202 patients were included. RP after HoLEP was technically feasible across open, laparoscopic, and robotic approaches. Operative time and the need for bladder-neck reconstruction were increased, reflecting post-enucleation fibrosis, but major complication rates (<5%) and blood loss were comparable to primary RP. Oncological outcomes were preserved, with positive surgical margin rates of 6–20% and biochemical recurrence rates of 7–15%, similar to those of primary RP. Functional recovery, particularly urinary continence, was slower initially but generally equivalent at 12 months. Erectile function outcomes were variable but satisfactory when nerve-sparing was feasible. Conclusions: Radical prostatectomy after HoLEP is a technically demanding yet safe procedure that achieves oncologic and long-term functional outcomes comparable to primary prostatectomy. Prior HoLEP should not preclude curative surgical management of prostate cancer, provided the operation is performed by experienced surgeons in high-volume centers. Full article
(This article belongs to the Special Issue Advances in the Diagnosis and Treatment of Prostate Cancer: From Biomarkers to Precision Surgery)
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