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Cancers
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Advanced Physiological Imaging of Hemodynamic and Functional Aspects of Cerebral...
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Advanced Physiological Imaging of Hemodynamic and Functional Aspects of Cerebral Glioma

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Methods and Technologies Development".

Deadline for manuscript submissions: closed (15 August 2023) | Viewed by 2414

Special Issue Editors

Dr. Jorn Fierstra

E-Mail Website
Guest Editor
1. Department of Neurosurgery, University Hospital Zurich, 8091 Zurich, Switzerland
2. Clinical Neuroscience Center, University Hospital Zurich, University of Zurich, 8057 Zurich, Switzerland
Interests: cerebrovascular reactivity; cerebral blood flow; fMRI; brain tumor; cerebrovascular disease
Special Issues, Collections and Topics in MDPI journals
Dr. Christiaan Hendrik Bas Van Niftrik

E-Mail Website
Guest Editor
1. Department of Neurosurgery, University Hospital Zurich, 8091 Zurich, Switzerland
2. Clinical Neuroscience Center, University Hospital Zurich, University of Zurich, 8057 Zurich, Switzerland
Interests: glioma; neuroimaging

Special Issue Information

Dear Colleagues,

Malignant cerebral glioma result in a complex pathophysiological behavior combined with an erratic growth pattern. Current morphological magnetic resonance imaging (MRI) techniques are considered the clinical gold standard to characterize malignant gliomas but are insufficient to characterize the pathophysiological behavior of these tumors, in particular with respect to their surroundings, and are insufficient to determine the complete tumor. Therefore, developments in advanced physiological imaging techniques based on either MRI or nuclear clinical imaging, such as positron emission tomography (PET), are becoming increasingly important in the evaluation and characterization of malignant cerebral gliomas for diagnostic, therapeutic, or prognostic purposes.

Furthermore, the increasing ability to better unravel the complex underlying molecular biology and pathophysiology of malignant cerebral gliomas may provide novel imaging biomarkers to gauge therapy responses. Contemporary research suggests an important role of vascular—glial—involvement, including hemodynamic alterations and cerebrovascular autoregulatory disturbances. From a functional perspective, malignant gliomas may also alter the neuronal response or functionality of surrounding functional tracts and induce neurovascular uncoupling or epilepsy.

This Special Issue will therefore offer a platform to present physiological neuroimaging advances that better characterize malignant cerebral glioma. Specifically, functional and hemodynamic imaging advances as well as advanced multimodal PET and MR imaging approaches will be favored. Furthermore, physiologic imaging of glioma-induced (epi)phenomena, such as epilepsy, neurovascular uncoupling and diaschisis, or imaging research efforts focusing on the relationship of gliomas with its structural surroundings (using, for instance, tractography, or transcranial magnetic stimulation), is highly desired. Studies on outcome propensities including hemodynamic and molecular imaging features are also welcomed.

Dr. Jorn Fierstra
Dr. Christiaan Hendrik Bas Van Niftrik
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • MRI
  • PET
  • TMS
  • malignant glioma
  • glioblastoma 
  • glioma recurrence 
  • glioma 
  • hemodynamic 
  • molecular 
  • functional 
  • epilepsy 
  • radiomics 
  • neurovascular uncoupling 
  • outcome 
  • autoregulation 
  • tractography 
  • blood flow

Published Papers (2 papers)

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Review

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20 pages, 10740 KiB  
Review
Detection and Mitigation of Neurovascular Uncoupling in Brain Gliomas
by Shruti Agarwal, Kirk M. Welker, David F. Black, Jason T. Little, David R. DeLone, Steven A. Messina, Theodore J. Passe, Chetan Bettegowda and Jay J. Pillai
Cancers 2023, 15(18), 4473; https://doi.org/10.3390/cancers15184473 - 08 Sep 2023
Cited by 2 | Viewed by 1179
Abstract
Functional magnetic resonance imaging (fMRI) with blood oxygen level-dependent (BOLD) technique is useful for preoperative mapping of brain functional networks in tumor patients, providing reliable in vivo detection of eloquent cortex to help reduce the risk of postsurgical morbidity. BOLD task-based fMRI (tb-fMRI) [...] Read more.
Functional magnetic resonance imaging (fMRI) with blood oxygen level-dependent (BOLD) technique is useful for preoperative mapping of brain functional networks in tumor patients, providing reliable in vivo detection of eloquent cortex to help reduce the risk of postsurgical morbidity. BOLD task-based fMRI (tb-fMRI) is the most often used noninvasive method that can reliably map cortical networks, including those associated with sensorimotor, language, and visual functions. BOLD resting-state fMRI (rs-fMRI) is emerging as a promising ancillary tool for visualization of diverse functional networks. Although fMRI is a powerful tool that can be used as an adjunct for brain tumor surgery planning, it has some constraints that should be taken into consideration for proper clinical interpretation. BOLD fMRI interpretation may be limited by neurovascular uncoupling (NVU) induced by brain tumors. Cerebrovascular reactivity (CVR) mapping obtained using breath-hold methods is an effective method for evaluating NVU potential. Full article
(This article belongs to the Special Issue Advanced Physiological Imaging of Hemodynamic and Functional Aspects of Cerebral Glioma)
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15 pages, 1148 KiB  
Systematic Review
Characterization and Classification of Spatial White Matter Tract Alteration Patterns in Glioma Patients Using Magnetic Resonance Tractography: A Systematic Review and Meta-Analysis
by Arash L. Mahmoodi, Maud J. F. Landers, Geert-Jan M. Rutten and H. Bart Brouwers
Cancers 2023, 15(14), 3631; https://doi.org/10.3390/cancers15143631 - 15 Jul 2023
Cited by 2 | Viewed by 899
Abstract
Introduction: Magnetic resonance (MR) tractography can be used to study the spatial relations between gliomas and white matter (WM) tracts. Various spatial patterns of WM tract alterations have been described in the literature. We reviewed classification systems of these patterns, and investigated whether [...] Read more.
Introduction: Magnetic resonance (MR) tractography can be used to study the spatial relations between gliomas and white matter (WM) tracts. Various spatial patterns of WM tract alterations have been described in the literature. We reviewed classification systems of these patterns, and investigated whether low-grade gliomas (LGGs) and high-grade gliomas (HGGs) demonstrate distinct spatial WM tract alteration patterns. Methods: We conducted a systematic review and meta-analysis to summarize the evidence regarding MR tractography studies that investigated spatial WM tract alteration patterns in glioma patients. Results: Eleven studies were included. Overall, four spatial WM tract alteration patterns were reported in the current literature: displacement, infiltration, disruption/destruction and edematous. There was a considerable heterogeneity in the operational definitions of these terms. In a subset of studies, sufficient homogeneity in the classification systems was found to analyze pooled results for the displacement and infiltration patterns. Our meta-analyses suggested that LGGs displaced WM tracts significantly more often than HGGs (n = 259 patients, RR: 1.79, 95% CI [1.14, 2.79], I2 = 51%). No significant differences between LGGs and HGGs were found for WM tract infiltration (n = 196 patients, RR: 1.19, 95% CI [0.95, 1.50], I2 = 4%). Conclusions: The low number of included studies and their considerable methodological heterogeneity emphasize the need for a more uniform classification system to study spatial WM tract alteration patterns using MR tractography. This review provides a first step towards such a classification system, by showing that the current literature is inconclusive and that the ability of fractional anisotropy (FA) to define spatial WM tract alteration patterns should be critically evaluated. We found variations in spatial WM tract alteration patterns between LGGs and HGGs, when specifically examining displacement and infiltration in a subset of the included studies. Full article
(This article belongs to the Special Issue Advanced Physiological Imaging of Hemodynamic and Functional Aspects of Cerebral Glioma)
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