Special Issue "Advances in Genetics of Hereditary Spastic Paraplegia"
A special issue of Brain Sciences (ISSN 2076-3425).
Deadline for manuscript submissions: closed (10 December 2018).
Interests: hereditary spastic paraplegia; genotype-phenotype correlation; axonal transport; axonal degeneration; myelopathy; spasticity
Hereditary spastic paraplegia (HSP) is a very diverse group of genetic disorders, resulting in stereotypical and otherwise undistinguishable clinical phenotype. The recent progress in identification of the causes of HSP has been staggering, with more than 80 different disease-causing genes identified and still counting. In spite of the advances in our understanding of its pathophysiology, including axonal transport disruption, abnormal organelle morphogenesis, impaired neuronal lipid homeostasis or mitochondrial dysfunction, therapy remains purely symptomatic.
In this Special Issue on the “Advances in Genetics of Hereditary Spastic Paraplegia”, I would like to invite manuscripts on variety of topics related to various aspects of HSP research, including new insights into genetics of HSP, pathophysiology, and clinical phenomenology with genotype-phenotype correlation analysis. Works in basic, translational or clinical sciences are welcome. Hopefully, this Special Issue will be of interest for both basic scientists and clinicians working in the field of HSP and axonal degeneration. I believe that the works published in this Special issue will be another stepping stone to new insights and ultimately better therapies for patients suffering from various forms of HSP.
Prof. Dr. Peter Hedera
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Brain Sciences is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Hereditary spastic paraplegia
- Genotype-phenotype correlation
- Axonal degeneration