Neuropsychiatric Symptoms as Windows into Neurodegenerative Processes and Neurocognitive Disorders
A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Neurodegenerative Diseases".
Deadline for manuscript submissions: 30 November 2026 | Viewed by 85
Special Issue Editors
2. Global Brain Health Institute, Medical School, Trinity College Dublin, Dublin, Ireland
3. Department of Psychiatry and Psychotherapy, Klinikum Rechts der Isar, Faculty of Medicine, Technical University of Munich, Munich, Germany
4. Patras Dementia Day Care Center, Patras, Greece
Interests: old-age depression; dementia; mild cognitive impairment; memory; neurodegeneration; neurobiology and brain physiology; cognitive neuroscience; neuroimaging; neurodegenerative diseases; cognitive neuropsychology; clinical neuropsychology; executive function
2. Fundación Las Rosas, Santiago, Chile
3. Sección de Geriatria, Hospital Clinico, Universidad de Chile, Santiago, Chile
4. Departamento de Psiquiatría, Universidad de Chile, Santiago, Chile
Interests: dementia; old age mental health; training
2. Global Brain Health Institute, Trinity College Dublin, Dublin, Ireland
3. SocioScript, Gurugram, India
Interests: psychosocial dimensions of neurocognitive disorders; community-based approaches to dementia care; dementia training; neuropsychology; neuroethics
Special Issue Information
Dear Colleagues,
Neuropsychiatric symptoms (NP) are a core pillar of the clinical phenotypes of neurocognitive disorders, which affect more than 90% of individuals at some point along the course of the syndrome trajectory. They may represent features of preclinical or oligosymptomatic phases of these disorders or emerge later in the continuum of the underlying pathogenic processes. However, the associations between NP and the brain changes that lead to neurocognitive disorders, as well as their relationships with biomarkers, etiological diagnoses and prognoses, remain poorly understood. This issue aims to shed light on (i) the complex associations between NP and clinical phenotypes, biomarkers and brain changes in neurocognitive disorders; (ii) the role of NP in the diagnostic process in the emerging era of biomarker-based diagnosis, including their relevance for differential diagnosis and treatment and (iii) the impact of NP on the conceptualization of neurocognitive disorders as clinical entities.
We welcome submissions, particularly original research and systematic reviews, that advance this integrative perspective.
Dr. Panagiotis Alexopoulos
Guest Editor
Dr. Tomas Ignacio Leon Rodríguez
Dr. Jayashree Dasgupta
Guest Editor Assistants
Manuscript Submission Information
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Keywords
- neuropsychiatric symptoms
- behavioral and psychological symptoms of dementia (BPSD)
- neurodegenerative diseases
- cognitive impairment
- dementia
- biomarkers
- disease progression
- neuroinflammation
- translational research
- dementia management
- non-pharmacological interventions
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