Cerebral Amyloid Angiopathy: Advances in the Field
A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Neurosurgery and Neuroanatomy".
Deadline for manuscript submissions: 20 April 2026 | Viewed by 30
Special Issue Editors
Interests: neuroradiology; stroke; cerebral amyloid angiopathy; cerebral small vessel disease; cerebral hemorrhage; biomarkers; MRI; CT
Special Issue Information
Dear Colleagues,
The Background and History of This Topic:
Cerebral amyloid angiopathy (CAA) is a frequent condition in the elderly, recognized as the leading cause of lobar haemorrhages, and, over time, the spectrum of clinical manifestations associated with CAA has expanded beyond haemorrhagic events to include cognitive decline, transient focal neurological episodes (TFNEs), microinfarcts, and white matter damage. Additionally, asymptomatic presentations, inflammatory forms (CAA-related inflammation—CAA-ri), hereditary variants, and iatrogenic CAA have been described, highlighting the complexity and heterogeneity of the disease. The close relationship between CAA and Alzheimer’s disease has also gained increasing attention, given the shared pathological substrate of amyloid deposition.
The Aim and Scope of this Special Issue:
This Special Issue aims to comprehensively explore CAA in all its forms, including its clinical, radiological, and pathological aspects. Special emphasis will be placed on diagnostic parameters — both established and emerging — while insights into the broader context of diseases overlapping with CAA are also welcome. Contributions that advance the understanding of pathophysiology, therapeutic strategies, and clinical outcomes are highly encouraged.
Cutting-Edge Research:
Recent research has focused on expanding diagnostic tools beyond traditional imaging, with CSF, blood biomarkers, and PET imaging gaining prominence. The recognition of inflammatory and hereditary subtypes, as well as iatrogenic forms, represents a cutting-edge development, highlighting the necessity for refined diagnostic criteria and targeted therapeutic approaches.
What Kind of Papers are Solicited:
We seek to submission of original research articles, comprehensive reviews, detailed case reports, and commentaries that contribute to the knowledge of CAA. Contributions can address diagnostic innovations, pathophysiological mechanisms, therapeutic interventions, disease progression, and outcome predictors. Studies exploring experimental biomarkers or novel imaging techniques are particularly welcome.
Dr. Ulf Jensen-Kondering
Dr. Benedetta Storti
Guest Editors
Manuscript Submission Information
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Keywords
- cerebral amyloid angiopathy
- cerebral small vessel disease
- cerebral hemorrhage
- vascular dementia
- stroke
- amyloid
- CAA-ri
- iatrogenic CAA
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