Special Issue "Stroke 2021: Recent Advances in Stroke Neuroprotection and Repair"

A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Neurodegenerative Diseases".

Deadline for manuscript submissions: 10 December 2021.

Special Issue Editor

Prof. Arieh Solomon
E-Mail Website
Guest Editor
Tel Aviv University, Goldschleger Eye Research Institute, Tel Aviv-Yafo, Israel

Special Issue Information

The latest World Health Organization report, released in May 2018, lists the top 10 causes of death worldwide in 2016. Of the 56.9 million deaths, half (54%) were due to the top 10 causes. Occupying the first two places of the list are ischemic heart diseases and stroke, the world's leading causes of death. It is estimated that more than 15 million deaths in 2016 were due to these causes. These diseases have remained the leading causes of death globally for the last 15 years.

Stroke is not only a prominent fatal disease but also the leading cause of disability worldwide. The cruel aspect of stroke is that it leaves people with severe functional disability and/or cognitive impairment. Stroke has a great impact on the economies worldwide, as it is estimated that about 10% of the male population and 8% of the female population are handicapped. Such people need personal help in their everyday life and must be materially supported by social services.  

Understanding the pathology of stroke in all its aspects may lead to the creation of a protocol of treatment that can prevent the assault. We hope that the present Special  Issue will be of interest and value for all physicians/practitioners.

Prof. Arieh Solomon
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Brain Sciences is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • pathology
  • stroke
  • cognitive impairment
  • severe functional disability

Published Papers (1 paper)

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Research

Article
Insulin Resistance in Skeletal Muscle of Chronic Stroke
Brain Sci. 2021, 11(1), 20; https://doi.org/10.3390/brainsci11010020 - 26 Dec 2020
Viewed by 777
Abstract
A stroke can lead to reduced mobility affecting skeletal muscle mass and fatty infiltration which could lead to systemic insulin resistance, but this has not been examined and the mechanisms are currently unknown. The objective was to compare the effects of in vivo [...] Read more.
A stroke can lead to reduced mobility affecting skeletal muscle mass and fatty infiltration which could lead to systemic insulin resistance, but this has not been examined and the mechanisms are currently unknown. The objective was to compare the effects of in vivo insulin on skeletal muscle glycogen synthase (GS) activity in paretic (P) and nonparetic (NP) skeletal muscle in chronic stroke, and to compare to nonstroke controls. Participants were mild to moderately disabled adults with chronic stroke (n = 30, 60 ± 8 years) and sedentary controls (n = 35, 62 ± 8 years). Insulin sensitivity (M) and bilateral GS activity were determined after an overnight fast and during a hyperinsulinemic-euglycemic clamp. Stroke subjects had lower aerobic capacity than controls, but M was not significantly different. Insulin-stimulated activities of GS (independent, total, fractional), as well as absolute differences (insulin minus basal) and the percent change (insulin minus basal, relative to basal) in GS activities, were all significantly lower in P versus NP muscle. Basal GS fractional activity was 3-fold higher, and the increase in GS fractional activity during the clamp was 2-fold higher in control versus P and NP muscle. Visceral fat and intermuscular fat were associated with lower M. The effect of in vivo insulin to increase GS fractional activity was associated with M in control and P muscle. A reduction in insulin action on GS in paretic muscle likely contributes to skeletal muscle-specific insulin resistance in chronic stroke. Full article
(This article belongs to the Special Issue Stroke 2021: Recent Advances in Stroke Neuroprotection and Repair)
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Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Dear Colleagues,

The latest World Health Organization report, released in May 2018, lists the top 10 causes of death worldwide in 2016. Of the 56.9 million deaths, half (54%) were due to the top 10 causes. Occupying the first two places of the list are ischemic heart diseases and stroke, the world's leading causes of death. It is estimated that more than 15 million deaths in 2016 were due to these causes. These diseases have remained the leading causes of death globally for the last 15 years.

Stroke is not only a prominent fatal disease but also the leading cause of disability worldwide. The cruel aspect of stroke is that it leaves people with severe functional disability and/or cognitive impairment. Stroke has a great impact on the economies worldwide, as it is estimated that about 10% of the male population and 8% of the female population are handicapped. Such people need personal help in their everyday life and must be materially supported by social services.  

Understanding the pathology of stroke in all its aspects may lead to the creation of a protocol of treatment that can prevent the assault. We hope that the present Special  Issue will be of interest and value for all physicians/practitioners.

Prof. Arieh Solomon
Guest Editor

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