New Therapeutic Strategies for Neurodegenerative Diseases: Alternative Methods of Clearing Pathogenic Proteins from the CNS

A special issue of Brain Sciences (ISSN 2076-3425).

Deadline for manuscript submissions: closed (31 August 2020) | Viewed by 234

Special Issue Editors

1. Department of Functional Biology, University of Oviedo, 33006 Oviedo, Spain
2. Instituto de Investigación Sanitaria del Principado de Asturias, 33011 Oviedo, Spain
Interests: neurodegenerative disorders; Alzheimer's disease; Huntington's disease; mouse models; protein aggregates; neurogenesis; microRNAs; exercise; CSF sink
Special Issues, Collections and Topics in MDPI journals
Department of Medicine, Universidad de Oviedo, Oviedo, Spain
Interests: Alzheimer; Parkinson; Biomarker; Frontotemporal Dementia; Lewy Bodies Dementia; Huntington; amyloid; tau; tdp43; synuclein
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

As most neurodegenerative diseases are proteinopathies, removing pathogenic proteins from the brain tissue remains the most straightforward therapeutic approach. Inhibiting the production of these pathogenic proteins or increasing their clearance by immunotherapy have shown promise in animal models but failed in clinical trials. Thus, alternative methods are needed to promote the clearance of pathogenic proteins in order to modify disease progression. Recently, new therapeutic interventions, such as albumin exchange in Alzheimer's disease and antisense oligonucleotide intrathecal administration in Huntington's disease, open a door to alternative methods of clearing pathogenic proteins from the CNS. These approaches suggest that it is possible to modify disease progression acting through the different compartments present in the CNS, giving rise to the development of new technologies that enable the development of innovative therapies.

Prof. Cristina Tomas-Zapico
Dr. Manuel Menéndez-González
Guest Editors

Manuscript Submission Information

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Keywords

  • Alzheimer’s disease
  • Parkinson’s disease
  • Lewy Bodies Dementia
  • Frontotemporal Dementia
  • Huntington’s disease
  • Amyotrophic Lateral Sclerosis
  • Beta-amyloid
  • Tau
  • TDP43
  • Alpha-synuclein
  • Huntingtin
  • Cerebrospinal fluid

Published Papers

There is no accepted submissions to this special issue at this moment.
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