Non-motor Disorders in Parkinson Disease: Basic Science and Advances in Treatment

Dear Colleagues,

It is our pleasure to introduce a Special Issue of Brain Science dedicated to basic neuroscience and clinical research about the neurobiology of non-motor symptoms (NMS) of Parkinson’s disease and potential treatment strategies.

Parkinson’s disease (PD) is the second most common neurodegenerative disorder, and although it is usually considered as a disorder that only affects movement, a broad spectrum of NMS can be observed in PD patients. Although the realities of the disease vary enormously from patient to patient, almost all of them have one or more NMS. In fact, a wide range of behavioural, neuropsychiatric and physical symptoms frequently play a primary role for the management of the disorder and constitute a major disease burden for patients and caregivers. Unfortunately, there is very little existing data about NMS, their neurobiology, and their treatment. It is therefore essential that researchers and practitioners comprehensively address the factors related to NMS if we want to achieve the best quality of life for PD patients.

The aim of this Special Issue is to provide an overview of evidence from clinical and basic research perspectives about Parkinson´s NMS. A non-exhaustive list of potential papers may include research involving the use of neurophysiology techniques, genetics, pharmacological therapy, physical therapy, psychological intervention in clinical populations, as well as preclinical studies with animal models.

With regard to the format of papers, we will consider research articles, opinion/perspective articles, and review articles (narrative review, systematic review, meta-analysis).

Dr. Patricia Martinez-Sanchez
Dr. Francisco Nieto-Escamez
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.