Bridging Neurodegeneration and Neuroinflammation: Novel Therapeutic Approaches

Dear Colleagues,

Neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, and traumatic brain injury are characterized by progressive neuronal loss and chronic neuroinflammation. Emerging evidence suggests that neuroinflammation is not merely a consequence but a driving force in the pathogenesis of these disorders. Bridging the gap between neurodegeneration and neuroinflammation is critical for developing effective therapeutic strategies.

This Special Issue, “Bridging Neurodegeneration and Neuroinflammation: Novel Therapeutic Approaches”, aims to highlight innovative interventions that target both neuronal damage and inflammatory cascades. A particular emphasis will be placed on transcriptomic insights that elucidate molecular signaling pathways in neurons, microglia, and astrocytes, including neuroinflammation, mTOR signaling, oxidative stress responses, autophagy, mitophagy, and synaptogenesis. Studies leveraging extracellular vesicles, drug-based therapies, and preclinical models to promote brain repair and resilience are especially encouraged.

We welcome original research articles, reviews, and systematic studies that advance our understanding of the interplay between neurodegeneration and neuroinflammation and propose novel therapeutic avenues.

Dr. Maheedhar Kodali
Guest Editor

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