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Brain Sciences
Special Issues
Cerebrovascular Diseases and Neuropsychological Sequelae
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Cerebrovascular Diseases and Neuropsychological Sequelae

A Special Issue of Brain Sciences (ISSN 2076-3425) belonging to the section "Neuropsychology".

Deadline for manuscript submissions: 30 October 2026 | Viewed by 557

Editors

Dr. Panayiotis Patrikelis

E-Mail Website
Guest Editor
Laboratory of Neuropsychology and Behavioral Neuroscience, Department of Psychology, Aristotle University of Thessaloniki, Thessaloniki, Greece
Interests: neuropsychology; vascular disorders; cognitive neurorehabilitation; neuromodulation
Dr. Themistoklis Papasilekas

E-Mail Website
Guest Editor
Department of Neurosurgery, Evaggelismos Hospital, Athens University Medical School, Athens, Greece
Interests: cerebrovascular diseases; brain aneurysms; brain’s arteriovenous malformations; stroke

Special Issue Information

Dear Colleagues,

The term cerebrovascular disease (CVD) refers to a group of conditions affecting blood flow to the brain, in the form of either ischemia or hemorrhage, leading to brain damage. Such conditions—whatever the underlying pathology—often involve cognitive impairment in their course, at least to some extent.

Due to the wide array of underlying pathologies and the variable nature of CVD-related issues, a multidisciplinary approach is essential in order for our community to gain insights into the complex cognitive, behavioral, and emotional manifestations of the disease and thus improve our daily clinical practice.

For this Special Issue, we welcome high-quality contributions that will help advance our knowledge on neuropsychological sequelae of CVD. We welcome original research articles, reviews, case reports, and theoretical articles that explore topics such as the following:

  • Innovative approaches to risk stratification and early detection of cognitive impairment in CVD;
  • Experimental and clinical studies on the pathophysiology of CVD-related cognitive effects;
  • Advances in cognition-targeted neurorehabilitation;
  • Pharmaceutical interventions for CVD-related cognitive impairment;
  • Surgical interventions for CVD and related cognitive impairment;
  • Studies on prognosis and predictors of cognitive neurorehabilitation outcomes;
  • Single-case neuropsychological studies with important clinical and theoretical implications.

We encourage submissions that combine scientific rigor with clinical relevance, aiming to bridge the gap between research and practice. Contributions highlighting new insights, novel methodologies, or translational applications that can inform patient-centered care are particularly welcome.

By gathering numerous cutting-edge works in a single Special Issue, our goal is to foster a deeper understanding of CVD-related cognitive and neurobehavioral impairments and promote differential neuropsychological diagnosis, rehabilitation, and prevention strategies. We invite researchers, clinicians, and scholars from across diverse disciplines to contribute to this timely and important publication.

Dr. Panayiotis Patrikelis
Dr. Themistoklis Papasilekas
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-anonymized peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Brain Sciences is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • cerebrovascular diseases (CVDs)
  • cognitive impairment
  • neuropsychology
  • neurorehabilitation
  • stroke
  • vascular dementia
  • brain aneurysms
  • hypertension

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

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Research

11 pages, 1409 KB  
Article
Perioperative Cognitive Decline in Verbal Associative Memory Following Carotid Revascularization and Subsequent Risk of Adverse Events: Clinical Significance of the Standard Verbal Paired Associate Learning Test (S-PA)
by Yasunobu Nakai, Sakura Kurosu, Taisuke Akimoto, Go Ikeda, Tomoko Chujo, Midori Kusakabe, Takuma Hara, Kazuya Uemura and Tetsuya Yamamoto
Brain Sci. 2026, 16(8), 877; https://doi.org/10.3390/brainsci16080877 - 18 Aug 2026
Viewed by 195
Abstract
Background/Objectives: This study aimed to explore whether perioperative changes in cognitive function following carotid artery revascularization, including carotid endarterectomy (CEA) and carotid artery stenting (CAS), are associated with subsequent clinical outcomes, focusing specifically on the Standard Verbal Paired Associate Learning Test (S-PA). Methods: [...] Read more.
Background/Objectives: This study aimed to explore whether perioperative changes in cognitive function following carotid artery revascularization, including carotid endarterectomy (CEA) and carotid artery stenting (CAS), are associated with subsequent clinical outcomes, focusing specifically on the Standard Verbal Paired Associate Learning Test (S-PA). Methods: This prospective, single-center study enrolled 69 patients who underwent CEA or CAS between June 2018 and June 2024. Neuropsychological assessments (Raven’s Colored Progressive Matrices (RCPM), Kohs Block Design Test for IQ (Kohs-IQ), the Trail Making Test (TMT)-A/B, and the Standard Verbal Paired Associate Learning Test (S-PA)) were conducted preoperatively and within seven days postoperatively. Patient characteristics and diagnostic imaging results, including magnetic resonance imaging (MRI), magnetic resonance angiography (MRA), and single-photon emission computed tomography (SPECT), were evaluated. Multivariate Cox proportional hazards models and Kaplan–Meier survival analyses were used to identify predictors of adverse outcomes, defined as recurrent stroke, restenosis, or mortality, during outpatient follow-up. Results: Fifteen patients experienced adverse outcomes during follow-up. Perioperative neuropsychological assessment showed that 36 patients experienced S-PA decline, indicating a tendency towards lower mean cerebral blood flow. Receiver operating characteristic (ROC) curve for perioperative ΔS-PA decline associated with adverse outcomes. The area under the curve (AUC) was 0.728. The optimal cutoff determined by the Youden index was a decline of 2 points (ΔS-PA ≤ −2), yielding a sensitivity of 73.3% and specificity of 68.5%. In a time-to-event analysis, S-PA decline was associated with adverse outcomes in an unadjusted analysis. A similar trend was observed in limited multivariable models; however, effect estimates were imprecise (HR = 4.01, 95% CI: 1.01–15.91, p = 0.048). Conclusions: This study indicates that perioperative decline in S-PA may reflect underlying cerebrovascular vulnerability and may be associated with subsequent adverse outcomes. However, given the limited number of events and potential for residual confounding, these findings should be interpreted with caution. Larger multicenter studies are required to validate these findings. Full article
(This article belongs to the Special Issue Cerebrovascular Diseases and Neuropsychological Sequelae)
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