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Brain Sciences
Special Issues
New Advances in Surgical Treatment of Brain Injury
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New Advances in Surgical Treatment of Brain Injury

A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Neurosurgery and Neuroanatomy".

Deadline for manuscript submissions: 15 November 2025 | Viewed by 1960

Special Issue Editors

Prof. Dr. Andres M. Rubiano

E-Mail Website
Guest Editor
1. NIHR Global Health Research Group on Neurotrauma, University of Cambridge, Cambridge CB2 1TN, UK
2. Neurosciences Institute, El Bosque University, Bogotá 11001, Colombia
Interests: TBI; neurocritical care; neuromonitoring
Special Issues, Collections and Topics in MDPI journals
Dr. Luigi Valentino Berra

E-Mail Website
Guest Editor
Department of Human Neuroscience, Sapienza University of Rome, 00185 Rome, Italy
Interests: neurosurgery; TBI; neuromonitoring

Special Issue Information

Dear Colleagues,

Traumatic brain injury (TBI) remains a leading cause of disability and mortality worldwide, requiring continuous advancements in surgical treatment. This Special Issue focuses on the latest innovations in neurosurgical approaches to brain injury, highlighting minimally invasive techniques and innovations on invasive monitoring techniques that are transforming patient care. The aim is to provide a comprehensive overview of emerging strategies, including the introduction of intracranial compartment syndrome (ICS) as a key concept for personalized treatment. This issue will explore cutting-edge research in real-time intracranial pressure (ICP) and brain tissue oxygenation (PbtO2) monitoring, novel surgical methods such as expansion craniotomy, and the integration of advanced minimally invasive techniques like cisternostomy and endoscopic management. We invite original research, clinical studies, and review articles that address novel surgical techniques, enhanced neuro-monitoring approaches, brain edema surgery, and the development of minimally invasive procedures aimed at improving patient outcomes.

Prof. Dr. Andres M. Rubiano
Dr. Luigi Valentino Berra
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Brain Sciences is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • traumatic brain injury
  • intracranial compartment syndrome
  • invasive monitoring
  • non-invasive neuroimaging
  • decompressive craniectomy
  • expansion craniotomy
  • hinge craniotomy
  • endoscopic neurosurgery
  • brain injury management

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Published Papers (1 paper)

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Research

14 pages, 656 KiB  
Article
A Randomized Controlled Trial Comparing Subcutaneous Preservation of Bone Flaps with Cryogenic Preservation of Bone Flaps for Cranioplasty in Cases of Traumatic Brain Injury
by Rachith Sridhar, Anil Kumar, Harendra Kumar, Abdul Vakil Khan, Abdul Hakeem, Deepak Kumar, Anurag Kumar and Majid Anwer
Brain Sci. 2025, 15(5), 514; https://doi.org/10.3390/brainsci15050514 - 17 May 2025
Viewed by 1825
Abstract
Background and objectives: Decompressive craniectomy (DC) is a surgical procedure, useful for relieving the intracranial pressure following trauma. Following reduction in cerebral oedema, the bone is placed back to cover the defect. During the interim period, the bone flap may be preserved using [...] Read more.
Background and objectives: Decompressive craniectomy (DC) is a surgical procedure, useful for relieving the intracranial pressure following trauma. Following reduction in cerebral oedema, the bone is placed back to cover the defect. During the interim period, the bone flap may be preserved using cryopreservation or in subcutaneous tissue. This leads to a need to determine the benefits and risks involved in preservation of bone flap in a subcutaneous pocket or conventional freezer following decompressive craniectomy in traumatic brain injury. Materials and methods: An open randomized controlled trial was conducted at a level one trauma centre from July 2023 to December 2024. Simple randomization was performed in order to allocate patients into the subcutaneous preservation group and the cryogenic preservation group. Patients underwent cranioplasty after 3 months and were followed up post-operatively for complications and Glasgow Outcome Scale assessment. Results: The study initially recruited a total of 158 patients, out of which 104 patients remained eligible for the final analysis. The patients with cryopreserved flaps were found to have a higher rate of surgical site infection (31.3%) as compared to those with subcutaneously preserved flaps (5.6%), with the differences being statistically significant (p < 0.001). Among the 87 patients who had a poorer Glasgow Outcome Scale (GOS) score before the intervention, 55 (63.2%) patients had at least some improvement in GOS over a period of one month. Conclusion: The use of subcutaneous preservation of bone is more beneficial in resource-limited settings as compared to conventional freezer storage. Full article
(This article belongs to the Special Issue New Advances in Surgical Treatment of Brain Injury)
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