Neurocognitive Dysfunction Following Brain Injury: Advances and Challenges
A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Molecular and Cellular Neuroscience".
Deadline for manuscript submissions: 31 January 2027 | Viewed by 277
Special Issue Editor
Special Issue Information
Dear Colleagues,
Brain injury is a major cause of long-term neurological and cognitive impairments. Accumulating evidence suggests that neuroinflammatory responses triggered by brain injury critically influence neuronal function and synaptic integrity. Following injury, glial cells—including microglia and astrocytes—become activated and initiate complex inflammatory signaling pathways that can profoundly influence neuronal excitability, synaptic transmission, and neural circuit activity.
Emerging studies indicate that dynamic communication between glial cells and neurons is a key determinant of neuronal dysfunction and cognitive deficits after brain injury. However, the molecular and cellular mechanisms underlying glia–neuron interactions and their impacts on synaptic integrity and neuronal signaling remain incompletely understood.
This Special Issue aims to highlight recent advances in the understanding of glia-mediated neuroinflammation and its consequences for neuronal signaling and synaptic function following brain injury. We particularly welcome studies addressing the following topics:
Glial activation and inflammatory signaling:
Mechanisms by which microglia and astrocytes respond to brain injury and initiate neuroinflammatory pathways.
Neuron–glia communication:
How bidirectional signaling between glial cells and neurons regulates neuronal activity and circuit function after injury.
Synaptic dysfunction and plasticity:
The impact of neuroinflammation on synaptic transmission, synaptic remodeling, and plasticity.
Molecular pathways and therapeutic targets:
Identification of novel signaling pathways and potential therapeutic strategies aimed at mitigating neuroinflammation and restoring cognitive function.
Collectively, this Special Issue seeks to provide new insights into the cellular and molecular mechanisms linking neuroinflammation to neuronal and synaptic dysfunction, ultimately contributing to improved therapeutic strategies for cognitive recovery following brain injury.
Dr. Xiaoying Sun
Guest Editor
Manuscript Submission Information
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Keywords
- brain injury
- neuroinflammation
- glia cells
- neuron–glia interaction
- synaptic plasticity
- cognitive dysfunction
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