Cellular and Molecular Mechanisms Underlying Aging Progression
A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Molecular and Cellular Neuroscience".
Deadline for manuscript submissions: 28 February 2026 | Viewed by 26
Special Issue Editor
Interests: neuroaging; neurodegeneration; iPSC-derived models; omics technologies; cellular senescence; neuroinflammation; longevity
Special Issue Information
Dear Colleagues,
Neuroaging is marked by mitochondrial dysfunction, oxidative stress, impaired proteostasis, chronic low-grade inflammation, and cellular senescence. These processes compromise neuronal functions and affect glial cells, including astrocytes and microglia, disrupting neuroprotection and synaptic maintenance and leading to heightened susceptibility to neurodegenerative diseases such as Alzheimer's and Parkinson's. Additionally, epigenetic changes and altered gene expression patterns shape the brain's resilience or susceptibility to degeneration. Recent breakthroughs in omics technologies, including transcriptomics, proteomics, and metabolomics, combined with single-cell analyses and advanced imaging methods, have shed new light on the intricate molecular networks governing neuroaging. Stem-cell-derived models, such as brain organoids and induced pluripotent stem cell (iPSC) systems, offer invaluable platforms for dissecting the cellular dynamics and molecular signatures associated with aging and neurodegenerative conditions. These innovative approaches hold the potential to unravel new therapeutic targets and biomarkers of brain aging, enabling precision medicine strategies to enhance overall brain health. This Special Issue welcomes research and reviews exploring these mechanisms, aiming to advance our understanding of neuroaging and foster innovative strategies for neuroprotection and resilience.
Dr. Mateus Vidigal de Castro
Guest Editor
Manuscript Submission Information
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Keywords
- neuroaging
- neurodegeneration
- iPSC-derived models
- omics technologies
- cellular senescence
- neuroinflammation
- longevity
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