Cellular and Molecular Mechanisms Underlying Aging Progression
A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Molecular and Cellular Neuroscience".
Deadline for manuscript submissions: 28 February 2026 | Viewed by 12
Special Issue Editor
Interests: neuroaging; neurodegeneration; iPSC-derived models; omics technologies; cellular senescence; neuroinflammation; longevity
Special Issue Information
Dear Colleagues,
Neuroaging is marked by mitochondrial dysfunction, oxidative stress, impaired proteostasis, chronic low-grade inflammation, and cellular senescence. These processes compromise neuronal functions and affect glial cells, including astrocytes and microglia, disrupting neuroprotection and synaptic maintenance and leading to heightened susceptibility to neurodegenerative diseases such as Alzheimer's and Parkinson's. Additionally, epigenetic changes and altered gene expression patterns shape the brain's resilience or susceptibility to degeneration. Recent breakthroughs in omics technologies, including transcriptomics, proteomics, and metabolomics, combined with single-cell analyses and advanced imaging methods, have shed new light on the intricate molecular networks governing neuroaging. Stem-cell-derived models, such as brain organoids and induced pluripotent stem cell (iPSC) systems, offer invaluable platforms for dissecting the cellular dynamics and molecular signatures associated with aging and neurodegenerative conditions. These innovative approaches hold the potential to unravel new therapeutic targets and biomarkers of brain aging, enabling precision medicine strategies to enhance overall brain health. This Special Issue welcomes research and reviews exploring these mechanisms, aiming to advance our understanding of neuroaging and foster innovative strategies for neuroprotection and resilience.
Dr. Mateus Vidigal de Castro
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Brain Sciences is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- neuroaging
- neurodegeneration
- iPSC-derived models
- omics technologies
- cellular senescence
- neuroinflammation
- longevity
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue policies can be found here.
