Advanced Clinical Diagnosis, Evaluation, and Treatment of Psychosis

Dear Colleagues,

Psychotic disorders represent the most prevalent psychiatric conditions with a significant impact on quality of life and functioning. The treatment of these conditions has historically been based on therapeutic strategies acting on the dopaminergic and serotonergic systems, with the main target of symptom remission. 

During the last decades, a precision approach to the diagnosis of affective and non-affective psychosis has been implemented, supported by research in the field of neuroimaging and biomarkers, possibly helping with the characterization of different clinical phenotypes that are beyond diagnostic boundaries. This has also led to the introduction of novel pharmacological and non-pharmacological interventions directed not only towards symptom resolution but also targeting the functioning dimension, with the major objective of full-functional recovery. Moreover, the “at-risk mental state” paradigm has promoted the new challenge of early diagnosis and intervention of psychotic disorders. 

All these topics will be addressed in this Special Issue, and thus all papers focusing on novel diagnostic and treatment approaches to psychotic disorders in different periods of life are welcome.

Dr. Giulia Menculini
Dr. Gaia Sampogna
Guest Editors

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