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Brain Sciences
Special Issues
Hypothalamic-Related Disorders
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Hypothalamic-Related Disorders

A special issue of Brain Sciences (ISSN 2076-3425). This special issue belongs to the section "Neurodegenerative Diseases".

Deadline for manuscript submissions: closed (15 May 2023) | Viewed by 6019

Special Issue Editors

Prof. Dr. Ali Rashidy-pour

E-Mail Website
Guest Editor
Research Center of Physiology, Semnan University of Medical Sciences, Semnan, Iran
Interests: electrophysiology; neurophysiology; neurobiology; neurobiology and brain physiology; learning and memory; physiology; neuroscience; memory; exercise; brain
Dr. Payman Raise Abdullahi

E-Mail Website
Guest Editor Assistant
Research Center of Physiology, Semnan University of Medical Sciences, Semnan, Iran
Interests: neurobiology of learning and memory; post-traumatic stress disorder; single-unit recording

Special Issue Information

Dear Colleagues,

Although the hypothalamus covers a small part of the brain, it strongly affects the function of the autonomic nervous system as well as hormones and plays a significant role in maintaining internal balance. The hypothalamus elaborately connects the nervous system and endocrine system; as a result, it is not an exaggeration to say that it has become the “command headquarters” or “smart control coordinator” of the body’s homeostasis. The hypothalamus is not only involved in the regulation of body temperature, blood pressure, heart rate, satiety, hunger, and thirst, but also the tuning of behavior, cognition, sleep, mood, and sex drive. The hypothalamus is an important hub of a network of neural structures regulating fear conditioning/extinction and plays a critical role in the pathophysiology of a variety of mood and cognitive disorders, especially through the HPA axis.

This Special Issue aims to present recent findings within this broad field of research, especially in cognitive, behavioral, and neurophysiological disorders related to hypothalamic dysfunction. Based on this, the topics include but are not limited to mood, cognition, behavior, learning and memory, stress, post-traumatic stress disorder, addiction, sleep, biological rhythms, brain development, etc. All research, including original, behavioral, neurobiological, neuroimaging, preclinical, and clinical studies as well as meta-analyses, and systematic or narrative reviews, is welcome to increase the richness of the “Hypothalamic-Related Disorders” Special Issue.

Prof. Dr. Ali Rashidy-pour
Guest Editor

Dr. Payman Raise Abdullahi
Guest Editor Assistant

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Brain Sciences is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • hypothalamic disorders
  • cognition
  • behavior
  • mood
  • learning and memory
  • stress
  • HPA axis
  • PTSD
  • addiction
  • biological rhythms

Published Papers (1 paper)

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Review

31 pages, 2495 KiB  
Review
Hypothalamus and Post-Traumatic Stress Disorder: A Review
by Payman Raise-Abdullahi, Morvarid Meamar, Abbas Ali Vafaei, Maryam Alizadeh, Masoomeh Dadkhah, Sakineh Shafia, Mohadeseh Ghalandari-Shamami, Ramtin Naderian, Seyed Afshin Samaei and Ali Rashidy-Pour
Brain Sci. 2023, 13(7), 1010; https://doi.org/10.3390/brainsci13071010 - 29 Jun 2023
Cited by 4 | Viewed by 5636
Abstract
Humans have lived in a dynamic environment fraught with potential dangers for thousands of years. While fear and stress were crucial for the survival of our ancestors, today, they are mostly considered harmful factors, threatening both our physical and mental health. Trauma is [...] Read more.
Humans have lived in a dynamic environment fraught with potential dangers for thousands of years. While fear and stress were crucial for the survival of our ancestors, today, they are mostly considered harmful factors, threatening both our physical and mental health. Trauma is a highly stressful, often life-threatening event or a series of events, such as sexual assault, war, natural disasters, burns, and car accidents. Trauma can cause pathological metaplasticity, leading to long-lasting behavioral changes and impairing an individual’s ability to cope with future challenges. If an individual is vulnerable, a tremendously traumatic event may result in post-traumatic stress disorder (PTSD). The hypothalamus is critical in initiating hormonal responses to stressful stimuli via the hypothalamic–pituitary–adrenal (HPA) axis. Linked to the prefrontal cortex and limbic structures, especially the amygdala and hippocampus, the hypothalamus acts as a central hub, integrating physiological aspects of the stress response. Consequently, the hypothalamic functions have been attributed to the pathophysiology of PTSD. However, apart from the well-known role of the HPA axis, the hypothalamus may also play different roles in the development of PTSD through other pathways, including the hypothalamic–pituitary–thyroid (HPT) and hypothalamic–pituitary–gonadal (HPG) axes, as well as by secreting growth hormone, prolactin, dopamine, and oxytocin. This review aims to summarize the current evidence regarding the neuroendocrine functions of the hypothalamus, which are correlated with the development of PTSD. A better understanding of the role of the hypothalamus in PTSD could help develop better treatments for this debilitating condition. Full article
(This article belongs to the Special Issue Hypothalamic-Related Disorders)
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