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8 August 2026
Brain Sciences | 2025 Editor’s Choice Publications from the “Systems Neuroscience” Section


This Section on systems neuroscience is dedicated to the research and exploration of multifactorial and multidimensional processes, such as normal and pathological aspects of sensory and motor functions; the activity of limbic and cognitive systems; and cerebral control of homeostasis, locomotion, reproduction, etc. By building a bridge between various theoretical concepts, basic science research, and clinical medicine applications, the “Systems Neuroscience’’ Section of the journal provides an in-depth analysis of the intricate workings of the nervous system. The focus of this section goes beyond isolated aspects of neuroscience research and dedicates itself to a more comprehensive view of neural mechanisms and functionality.

All articles published in our journal are available in an open access format, granting you unrestricted access to the full free text. We invite you to explore our 2025 Editor’s Choice Publications from Section “Systems Neuroscience”, listed below as follows:

1. “Relationship Between Sedentary Lifestyle, Physical Activity and Stress in University Students and Their Life Habits: A Scoping Review with PRISMA Checklist (PRISMA-ScR)”
by Mariasole Antonietta Guerriero, Anna Dipace, Antonietta Monda, Antonella De Maria, Rita Polito, Giovanni Messina, Marcellino Monda, Marilena di Padova, Angelo Basta, Maria Ruberto et al.
Brain Sci. 2025, 15(1), 78; https://doi.org/10.3390/brainsci15010078

2. “Specialized Large Language Model Outperforms Neurologists at Complex Diagnosis in Blinded Case-Based Evaluation”
by Sami Barrit, Nathan Torcida, Aurelien Mazeraud, Sebastien Boulogne, Jeanne Benoit, Timothée Carette, Thibault Carron, Bertil Delsaut, Eva Diab, Hugo Kermorvant et al.
Brain Sci. 2025, 15(4), 347; https://doi.org/10.3390/brainsci15040347

3. “Anti-NMDA Receptor Encephalitis: A Narrative Review”
by Vlad Pădureanu, Dalia Dop, Rodica Pădureanu, Denisa Floriana Vasilica Pîrșcoveanu, Gabriela Olaru, Ioana Streata and Ana Maria Bugă
Brain Sci. 2025, 15(5), 518; https://doi.org/10.3390/brainsci15050518

4. “Epidemiology of Tourette Syndrome”
by Abdullah Yasir Yilmaz and Joseph Jankovic
Brain Sci. 2025, 15(5), 426; https://doi.org/10.3390/brainsci15050426

5. “Lactylation and Central Nervous System Diseases”
by Ye Chen, Dongqiong Xiao and Xihong Li
Brain Sci. 2025, 15(3), 294; https://doi.org/10.3390/brainsci15030294

6. “Neurodevelopmental Tics with Co-Morbid Functional Tic-like Behaviors: Diagnostic Challenges of a Complex Tourette Syndrome Phenotype”
by Andrea Eugenio Cavanna, Virginia Caimi, Elisa Capriolo, Matteo Marinoni, Gabriele Arienti, Anna Riva, Renata Nacinovich and Stefano Seri
Brain Sci. 2025, 15(5), 435; https://doi.org/10.3390/brainsci15050435

7. “Acute Ischemic Stroke Treatment in Germany (2015–2023): Nationwide Trends in Thrombolysis and Thrombectomy by Age and Sex”
by Sara Hirsch, Karel Kostev, Christian Tanislav and Ali Hammed
Brain Sci. 2025, 15(8), 832; https://doi.org/10.3390/brainsci15080832

8. “Neurocognitive Impairment After COVID-19: Mechanisms, Phenotypes, and Links to Alzheimer’s Disease”
by Triantafyllos Doskas, George D. Vavougios, Constantinos Kormas, Christos Kokkotis, Dimitrios Tsiptsios, Kanellos C. Spiliopoulos, Anna Tsiakiri, Foteini Christidi, Tamara Aravidou, Liberis Dekavallas et al.
Brain Sci. 2025, 15(6), 564; https://doi.org/10.3390/brainsci15060564

9. “Tracking Changes in Corticospinal Excitability During Visuomotor Paired Associative Stimulation to Predict Motor Resonance Rewriting”
by Giacomo Guidali and Nadia Bolognini
Brain Sci. 2025, 15(3), 257; https://doi.org/10.3390/brainsci15030257

10. “Effects of a 12-Week Moderate-to-High Intensity Strength Training Program on the Gait Parameters and Their Variability of Stroke Survivors”
by Georgios Giarmatzis, Erasmia Giannakou, Ioanna Karagiannakidou, Evangelia Makri, Anna Tsiakiri, Foteini Christidi, Paraskevi Malliou, Konstantinos Vadikolias and Nikolaos Aggelousis
Brain Sci. 2025, 15(4), 354; https://doi.org/10.3390/brainsci15040354

11. “Synergistic Effects of Joint-Biased Rehabilitation and Combined Transcranial Direct Current Stimulation (tDCS) in Chronic Ankle Instability: A Single-Blind, Three-Armed Randomized Controlled Trial”
by Yunseo Kim, Hyunjoong Kim, Jihye Jung and Seungwon Lee
Brain Sci. 2025, 15(5), 458; https://doi.org/10.3390/brainsci15050458

12. “Age- and Sex-Specific Gut Microbiota Signatures Associated with Dementia-Related Brain Pathologies: An LEfSe-Based Metagenomic Study”
by Sun Hwa Hong, Hyun Woong Roh, You Jin Nam, Tae Wi Kim, Yong Hyuk Cho, Sang Joon Son and Chang Hyung Hong
Brain Sci. 2025, 15(6), 611; https://doi.org/10.3390/brainsci15060611

13. “Vagus Nerve Stimulation in Stroke Management: Brief Review of Evolution and Present Applications Paired with Rehabilitation”
by Prasad S. Vannemreddy, Mark Cummings, Romana V. Bahrii and Konstantin V. Slavin
Brain Sci. 2025, 15(4), 346; https://doi.org/10.3390/brainsci15040346

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