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Nanomaterials-Based Biosensor Platforms for Environmental and Biomedical Applications

A special issue of Materials (ISSN 1996-1944). This special issue belongs to the section "Advanced Nanomaterials and Nanotechnology".

Deadline for manuscript submissions: closed (20 August 2023) | Viewed by 1054

Special Issue Editors


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Guest Editor
Department of Environmental Sciences, Institute Jožef Stefan,Jamova 39, 1000 Ljubljana, Slovenia
Interests: biosensors; nanomaterials; antibodies; synthesis; nanoparticles; microbiology; molecular biology; surface chemistry; bioconjugation and supramolecular chemistry
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Guest Editor
DBT-National Institute of Animal Biotechnology (DBT-NIAB), Opp Journalist Colony, Near Gowlidoddy Extended, Wipro Cir, Gachibowli, Hyderabad, Telangana 500032, India
Interests: biosensors; bioengineering; nanomaterials; nano-carriers; diagnostics; therapy; imaging; nanoparticles and nano-energy
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Centre for Advanced Materials Application SAS, Dúbravská cesta 5807/9, 845 11 Bratislava, Slovakia
Interests: nanomaterial synthesis; aerogel; nanoparticles; supramolecular chemistry; polymers

Special Issue Information

Dear Colleagues,

Recent developments in the field of biosensors using nanomaterials as sensing transducing materials have gained immense importance in recent years because of their physical and chemical properties. Various emerging nanomaterials (eg. MXenes, graphene, graphitic carbon nitride, carbon nanotubes, fullerene, quantum dots and rare earth nanoparticles) as well as hybrid materials, have been used to develop advanced sensitivity, selectivity and representability. Utilizing these materials as central core sensing components, different biosensors platforms have been developed, including nanomaterials-based sensors for aptamer, protein, antibodies, SARS-CoV-2, MARS, electrochemiluminescence, peptide-based sensing, pesticides, biomarkers and SARS (Surface-enhanced Raman Scattering).

This Special Issue highlights the recent advancements in nanomaterial-based biosensors and their potential application in the environmental and biomedical fields. Original research articles and peer review papers (full-length or shorter) are welcome.

Dr. Raghuraj Singh Chouhan
Dr. Sonu Gandhi
Dr. Veera Bhadraiah Sadhu
Guest Editors

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • emerging nanomaterials and their application in biosensors
  • nanomaterial synthesis and application in biosensors
  • nanomaterial-based biosensors for environmental applications
  • nanostructure and chemistry of biosensors
  • biosensors for biomedical applications

Published Papers (1 paper)

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Research

16 pages, 5608 KiB  
Article
Clarithromycin-Loaded Submicron-Sized Carriers: Pharmacokinetics and Pharmacodynamic Evaluation
by Reetika Rawat, Raghuraj Singh Chouhan, Veera Sadhu and Manu Sharma
Materials 2023, 16(9), 3593; https://doi.org/10.3390/ma16093593 - 8 May 2023
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Abstract
The current study aims to improve clarithromycin bioavailability and effectiveness in complicated intra-abdominal infection management. Therefore, clarithromycin-loaded submicron dual lipid carriers (CLA-DLCs) were developed via hot high shear homogenization technique and evaluated for colloidal parameters, release behavior, stability study, and in-vitro antibiofilm activity. [...] Read more.
The current study aims to improve clarithromycin bioavailability and effectiveness in complicated intra-abdominal infection management. Therefore, clarithromycin-loaded submicron dual lipid carriers (CLA-DLCs) were developed via hot high shear homogenization technique and evaluated for colloidal parameters, release behavior, stability study, and in-vitro antibiofilm activity. Bioavailability and therapeutic efficacy of optimized formulation on hampering cytokines storm induction was determined in E. coli-induced peritonitis. The developed CLA-DLCs (particle size 326.19 ± 24.14 nm, zeta potential −31.34 ± 2.81 mV, and entrapment efficiency 85.78 ± 4.01%) exhibited smooth spherical shapes and sustained in vitro release profiles. Long-term stability study of optimized CLA-DLCs ensured maintenance of colloidal parameters for 1 year at room temperature. In vitro antimicrobial studies revealed 3.43-fold higher anti-biofilm activity of CLA-DLCs compared with clarithromycin. In addition, the relative bioavailability of CLA-DLCs was enhanced 5.89-fold compared to pure drug in rats. The remarkable decrease in microbial burden in blood as well as tissues, along with oxidative stress markers (lipid peroxidation, myeloperoxidase activity, and carbonylated protein level) and immunological markers (total leukocyte count, neutrophil migration, NO, TNF-, and IL-6) on treatment with CLA-DLCs enhanced the survival in a rat model of peritonitis compared with the pure drug and untreated groups. In conclusion, CLA-DLCs hold promising potential in management of intra-abdominal infections and prevention of associated complications. Full article
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