Lab-on-a-Chip Devices and Biosensors to Model Biological Barriers

Dear Colleagues,

The importance of integrated biochips for studying biological barriers in vitro has been increased in the last decade. With the possibility of the coculturing of multiple cell types and to integrate spheroids and organoids, these lab-on-a-chip devices offer effective ways to understand physiological functions, transport mechanisms, drug delivery and pathologies. Biological barriers include the skin, cornea, respiratory and gastrointestinal epithelial barriers, which are the first to come in contact with the outside environment. In the body, endothelial and epithelial cells form barriers in the testis, placenta and in the brain (blood–brain barrier, choroid plexus, blood–retina barrier). These protect the specific organ systems from outside damage and maintain ionic and nutritional homeostasis within the tissue. Integrated microelectronic biochips provide a complex hardware for multicellular barrier culture modelling, including several crucial parameters needed for effective translational studies. With the newly emerging concept of human stem cell-derived models and organoids, the field has never been more complex. This Special Issue provides a platform to feature novel developments on the miniaturized microfluidic biochip device family, integrating all types of measurements. This includes barrier integrity measurements, morphology characterizations, physiology and pathology investigations, protection in diseases, novel ways of drug targeting, and gene and protein expression studies.

Prof. Dr. András Dér
Prof. Dr. Mária A. Deli
Dr. András Kincses
Dr. Fruzsina Walter
Guest Editors

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