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Biosensors
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Graphene Oxide-Based Biosensors
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Graphene Oxide-Based Biosensors

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensor Materials".

Deadline for manuscript submissions: closed (30 November 2021) | Viewed by 12384

Special Issue Editor

Prof. Dr. Stella Girousi

E-Mail Website
Guest Editor
Chemistry Department, Analytical Chemistry Laboratory, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
Interests: analytical chemistry; electroanalysis; electrochemical biosensors; nanobiosensors
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Graphene and its oxide, graphene oxide (GO), are among the new materials that can serve as electrode surfaces in the development of promising electrode configurations. Graphene is an allotrope of carbon consisting of a single layer of atoms arranged in a two-dimensional honeycomb lattice. Graphene itself is promising material due to its unique physical and chemical properties such as flexibility, bio-compatibility, and conductivity.

Graphene and graphene oxide (GO) hold great promise in the development of biosensors and their applications in solving problems in chemical analysis.

This Special Issue describes GO-based biosensors developed by outstanding research groups in the scientific discipline of analytical chemistry.

Dr. Girousi Stella
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Graphene
  • graphene oxide
  • electrode
  • biosensor
  • electrochemical biosensor

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Published Papers (3 papers)

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Research

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16 pages, 3936 KiB  
Article
Graphene-Oxide and Ionic Liquid Modified Electrodes for Electrochemical Sensing of Breast Cancer 1 Gene
by Deniz Işın, Ece Eksin and Arzum Erdem
Biosensors 2022, 12(2), 95; https://doi.org/10.3390/bios12020095 - 4 Feb 2022
Cited by 21 | Viewed by 3206
Abstract
Graphene-oxide and ionic liquid composite-modified pencil graphite electrodes (GO-IL-PGEs) were developed and used as a sensing platform for breast cancer 1 (BRCA1) gene detection. The characterization of GO-IL modified electrodes was executed by scanning electron microscopy (SEM), cyclic voltammetry (CV), and electrochemical impedance [...] Read more.
Graphene-oxide and ionic liquid composite-modified pencil graphite electrodes (GO-IL-PGEs) were developed and used as a sensing platform for breast cancer 1 (BRCA1) gene detection. The characterization of GO-IL modified electrodes was executed by scanning electron microscopy (SEM), cyclic voltammetry (CV), and electrochemical impedance spectroscopy (EIS). The nucleic-acid hybridization was monitored by a differential pulse voltammetry (DPV) technique by directly measuring the guanine oxidation signal without using any indicator. The effects of the IL concentration, the probe concentration, and the hybridization time were optimized to the biosensor response. The limit of detection (LOD) was calculated in the concentration range of 2–10 μg/mL for the BRCA1 gene and found to be 1.48 µg/mL. The sensitivity of the sensor was calculated as 1.49 µA mL/µg cm2. The developed biosensor can effectively discriminate the complementary target sequence in comparison to a three-base-mismatched sequence or the non-complementary one. Full article
(This article belongs to the Special Issue Graphene Oxide-Based Biosensors)
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18 pages, 4182 KiB  
Article
Selective Voltammetric Detection of Ascorbic Acid from Rosa Canina on a Modified Graphene Oxide Paste Electrode by a Manganese(II) Complex
by Sophia Karastogianni, Dimitra Diamantidou and Stella Girousi
Biosensors 2021, 11(9), 294; https://doi.org/10.3390/bios11090294 - 25 Aug 2021
Cited by 13 | Viewed by 3294
Abstract
Voltammetric techniques have been considered as an important analytical tool applied to the determination of trace concentrations of many biological molecules including ascorbic acid. In this paper, ascorbic acid was detected by square wave voltammetry, using graphene oxide paste as a working electrode, [...] Read more.
Voltammetric techniques have been considered as an important analytical tool applied to the determination of trace concentrations of many biological molecules including ascorbic acid. In this paper, ascorbic acid was detected by square wave voltammetry, using graphene oxide paste as a working electrode, modified by a film of a manganese(II) complex compound. Various factors, such as the effect of pH, affecting the response characteristics of the modified electrode were investigated. The relationship between the peak height and ascorbic acid concentration within the modified working electrode was investigated, using the calibration graph. The equation of the calibration graph was found to be: I = 0.0550γac + 0.155 with R2 = 0.9998, where I is the SWV current and γac is the mass concentration of ascorbic acid. The LOD and LOQ of the proposed method were determined to be 1.288 μg/L and 3.903 μg/L, respectively. Several compounds, such as riboflavin, biotin, and ions, such as Fe and Cu, were tested and it seemed that they did not interfere with the analytic signal. The proposed procedure was successfully applied in the determination of ascorbic acid in Rosa canina hips. Full article
(This article belongs to the Special Issue Graphene Oxide-Based Biosensors)
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Review

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41 pages, 6874 KiB  
Review
Current Perspectives in Graphene Oxide-Based Electrochemical Biosensors for Cancer Diagnostics
by Dilsat Ozkan-Ariksoysal
Biosensors 2022, 12(8), 607; https://doi.org/10.3390/bios12080607 - 6 Aug 2022
Cited by 26 | Viewed by 4732
Abstract
Since the first commercial biosensor device for blood glucose measurement was introduced in the 1970s, many “biosensor types” have been developed, and this research area remains popular worldwide. In parallel with some global biosensor research reports published in the last decade, including a [...] Read more.
Since the first commercial biosensor device for blood glucose measurement was introduced in the 1970s, many “biosensor types” have been developed, and this research area remains popular worldwide. In parallel with some global biosensor research reports published in the last decade, including a great deal of literature and industry statistics, it is predicted that biosensor design technologies, including handheld or wearable devices, will be preferred and highly valuable in many areas in the near future. Biosensors using nanoparticles still maintain their very important place in science and technology and are the subject of innovative research projects. Among the nanomaterials, carbon-based ones are considered to be one of the most valuable nanoparticles, especially in the field of electrochemical biosensors. In this context, graphene oxide, which has been used in recent years to increase the electrochemical analysis performance in biosensor designs, has been the subject of this review. In fact, graphene is already foreseen not only for biosensors but also as the nanomaterial of the future in many fields and is therefore drawing research attention. In this review, recent and prominent developments in biosensor technologies using graphene oxide (GO)-based nanomaterials in the field of cancer diagnosis are briefly summarized. Full article
(This article belongs to the Special Issue Graphene Oxide-Based Biosensors)
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