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Biosensors
Special Issues
Electrochemical and Fluorescent Biosensors: Novel Strategies, Methods, and Materials II
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Electrochemical and Fluorescent Biosensors: Novel Strategies, Methods, and Materials II

A special issue of Biosensors (ISSN 2079-6374). This special issue belongs to the section "Biosensor and Bioelectronic Devices".

Deadline for manuscript submissions: closed (28 February 2025) | Viewed by 4811

Special Issue Editors

Dr. Baiqing Yuan

E-Mail Website
Guest Editor
School of Chemistry and Materials Science, Ludong University, Yantai, China
Interests: biothiol sesnors; electrochemical sensors; electrocatalysis
Special Issues, Collections and Topics in MDPI journals
Dr. Lin Liu

E-Mail Website
Guest Editor
Henan Province of Key Laboratory of New Optoelectronic Functional Materials, Anyang Normal University, Anyang, China
Interests: biosensors; electrocatalysts; self-assembly; metal–peptide complexes; nanomaterials; signal amplification
Special Issues, Collections and Topics in MDPI journals
Dr. Lijun Zhao

E-Mail Website
Guest Editor
School of Chemistry and Chemical Engineering,Yantai University, Yantai, China
Interests: photoelectric analysis and molecular catalysis
Special Issues, Collections and Topics in MDPI journals
Dr. Daojun Zhang

E-Mail Website
Guest Editor
College of Chemistry and Chemical Engineering, Anyang Normal University, Anyang, China
Interests: electrochemical sensing; OER electrocatalysts, and supercapacitors; fabrication of inorganic nanomaterials for electrochemical energy storage and conversion
Special Issues, Collections and Topics in MDPI journals
Dr. Dong Liu

E-Mail Website
Guest Editor
School of Agricultural Engineering, Jiangsu University, Zhenjiang 212013, China
Interests: photoelectrocehmical and elecrochemical biosensing
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

A typical biosensor consists of two basic functional units: a biological receptor and a transducer. The receptor (for example, an enzyme, antibody or DNA) is responsible for the selective recognition of the target analyte, while the transducer translates this biorecognition event into a chemical or physical signal. Recently, artificial materials, such as molecularly imprinted polymers, aptamers, nanomaterials, nanoenzymes, and peptide nucleic acids (PNAs), have also been used as recognition elements. Electrochemical and fluorescent biosensors have received a great deal of attention owing to their advantages in in vivo analysis, wearable applications, real-time monitoring, and quantitative imaging.

Contributions to this Special Issue should cover advances in electrochemical and fluorescent biosensors in terms of novel strategies, methods, and materials. Themes of interest include, but are not limited to:

  1. Biosensors with electrochemical, electrochemiluminescent, and fluorescent transduction for healthcare monitoring, biomedical applications, disease diagnostics, environmental monitoring, food analysis, and online control in industrial processes, etc.;
  2. Novel materials for the efficient immobilization of biological molecules; for example, two-dimensional graphene oxide containing abundant oxo-functionalities and sp2domains allows for interaction/anchoring with a wide range of biomolecules;
  3. Biosensors based on artificial recognition elements (for example, nanomaterials, nanoenzymes, etc.);
  4. Novel recognition elements developed for biosensors;
  5. Novel strategies for biofouling-resistant performance;
  6. Wearable noninvasive or invasive biosensors;
  7. Miniaturized biosensors and microscale and nanoscale biosensors;
  8. Signal amplification strategies for biosensors;
  9. Biosensors extended to devices which utilize biological elements and/or biochemical reactions to detect chemical or biological molecules;
  10. Nonenzymatic electrochemical sensors for the detection of biological molecules with high selectivity.

Dr. Baiqing Yuan
Dr. Lin Liu
Dr. Lijun Zhao
Dr. Daojun Zhang
Dr. Dong Liu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biosensors is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biosensors
  • electrochemical
  • electrochemiluminescent
  • fluorescent
  • antifouling
  • nano enzyme
  • wearable biosensors
  • miniaturized biosensors
  • nanoscale biosensors
  • signal amplification

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (3 papers)

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Research

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12 pages, 2070 KiB  
Article
Ultrasensitive Electrochemical Biosensor for Rapid Screening of Chemicals with Estrogenic Effect
by Ruixin Li, Jin Li, Xianbo Lu, Fanli Meng and Jiping Chen
Biosensors 2024, 14(9), 436; https://doi.org/10.3390/bios14090436 - 9 Sep 2024
Viewed by 1289
Abstract
Estrogenic chemicals are widely distributed and structurally diverse. They primarily disrupt estrogen-related metabolism in animals or humans by mimicking the agonistic receptor effects of natural estrogens, thereby influencing the transcription of estrogen receptors to regulate their quantity and sensitivity. This disruption of estrogen-related [...] Read more.
Estrogenic chemicals are widely distributed and structurally diverse. They primarily disrupt estrogen-related metabolism in animals or humans by mimicking the agonistic receptor effects of natural estrogens, thereby influencing the transcription of estrogen receptors to regulate their quantity and sensitivity. This disruption of estrogen-related metabolism can lead to estrogen-related effects, posing risks to biological health, emphasizing the urgent need for simple and effective methods to screen compounds with estrogenic effects. Herein, a new electrochemical biological effect biosensor based on human estrogen receptor α (hERα) is developed, which uses hERα as the biorecognition element and employs the electroactive horseradish peroxidase (HRP) labeled 17β-estradiol (E2) multifunctional conjugate HRP-E2 as the signal-boosting element and ligand competition agent. Based on the specific ligand–receptor interaction principle between the target and nuclear receptor, by allowing the test compound to compete with HRP-E2 conjugate for binding to hERα and testing the electrocatalytic signal of the conjugate that fails to bind to the hERα estrogen receptor, rapid screening and quantitative detection of chemical substances with estrogenic effect have been achieved. The biosensor shows a wide linear range of 40 pM to 40 nM with a detection limit of 17 pM (S/N = 3) for E2, and the detection limit is 2 orders of magnitude better than that of the previously reported sensors. The biosensor based on ligand–receptor binding can not only quantitatively analyze the typical estrogen E2, but also evaluate the relative estrogen effect strength of other estrogen compounds, which has good stability and selectivity. This electrochemical sensing platform displays its promising potential for rapid screening and quantitative detection of chemicals with estrogenic effects. Full article
(This article belongs to the Special Issue Electrochemical and Fluorescent Biosensors: Novel Strategies, Methods, and Materials II)
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13 pages, 3302 KiB  
Article
Solid-Phase Electrochemiluminescence Enzyme Electrodes Based on Nanocage Arrays for Highly Sensitive Detection of Cholesterol
by Xinying Ma, Zhe Zhang, Yanyan Zheng and Jiyang Liu
Biosensors 2024, 14(8), 403; https://doi.org/10.3390/bios14080403 - 21 Aug 2024
Cited by 14 | Viewed by 1369
Abstract
The convenient and sensitive detection of metabolites is of great significance for understanding human health status and drug development. Solid-phase electrochemiluminescence (ECL) enzyme electrodes show great potential in metabolite detection based on the enzyme-catalyzed reaction product hydrogen peroxide (H2O2). [...] Read more.
The convenient and sensitive detection of metabolites is of great significance for understanding human health status and drug development. Solid-phase electrochemiluminescence (ECL) enzyme electrodes show great potential in metabolite detection based on the enzyme-catalyzed reaction product hydrogen peroxide (H2O2). Herein, a solid-phase ECL enzyme sensor was fabricated based on a confined emitter and an immobilized enzyme using electrostatic nanocage array, constructing a platform for the sensitive detection of cholesterol. The electrostatic cage nanochannel consists of a bipolar and bilayer vertically aligned mesoporous silica film (bp-VMSF). The upper layer of bp-VMSF is an amino-modified, positively charged VMSF (p-VMSF), and the lower layer is a negatively charged VMSF (n-VMSF). The most commonly used ECL probe tris(bipyridine)ruthenium(II) (Ru(bpy)32+) is fixed in n-VMSF by electrostatic adsorption from n-VMSF and electrostatic repulsion from the upper p-VMSF, generating significantly enhanced and stable ECL signals. The successful preparation of the electrostatic cage was characterized by scanning electron microscopy (SEM) and electrochemical methods. After amino groups on the outer surface of bp-VMSF were derivatized with aldehyde, cholesterol oxidase (ChOx) molecules were covalently immobilized. The successful construction of the enzyme electrode was characterized by cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). When the corresponding enzyme substrate, cholesterol, was present in the solution, the ECL signal of Ru(bpy)32+ was quenched by the enzyme-catalyzed reaction product H2O2, enabling the high-sensitivity detection of cholesterol. The linear range for detecting cholesterol was from 0.05 mM to 5.0 mM, with a limit of detection (LOD) of 1.5 μM. Full article
(This article belongs to the Special Issue Electrochemical and Fluorescent Biosensors: Novel Strategies, Methods, and Materials II)
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Review

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19 pages, 6173 KiB  
Review
Optical Bioassays Based on the Signal Amplification of Redox Cycling
by Yunxiao Feng, Fengli Gao, Xinyao Yi and Ming La
Biosensors 2024, 14(6), 269; https://doi.org/10.3390/bios14060269 - 24 May 2024
Cited by 1 | Viewed by 1513
Abstract
Optical bioassays are challenged by the growing requirements of sensitivity and simplicity. Recent developments in the combination of redox cycling with different optical methods for signal amplification have proven to have tremendous potential for improving analytical performances. In this review, we summarized the [...] Read more.
Optical bioassays are challenged by the growing requirements of sensitivity and simplicity. Recent developments in the combination of redox cycling with different optical methods for signal amplification have proven to have tremendous potential for improving analytical performances. In this review, we summarized the advances in optical bioassays based on the signal amplification of redox cycling, including colorimetry, fluorescence, surface-enhanced Raman scattering, chemiluminescence, and electrochemiluminescence. Furthermore, this review highlighted the general principles to effectively couple redox cycling with optical bioassays, and particular attention was focused on current challenges and future opportunities. Full article
(This article belongs to the Special Issue Electrochemical and Fluorescent Biosensors: Novel Strategies, Methods, and Materials II)
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