Protein Engineering: The Present and the Future 2.0
A special issue of Biophysica (ISSN 2673-4125).
Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 3850
Special Issue Editors
Interests: protein stability; protein engineering; protein folding; biocomputation; drug discovery
Special Issues, Collections and Topics in MDPI journals
Interests: metabolic reprogramming in cancer cells ageing and neural diseases; metabolism of small dinucleotides involved in the formation of bacterial biofilm in chronic infections; role of nitric oxide and redox metabolism in bacterial pathogens and eukaryotic cells
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Special Issue Information
Dear Colleagues,
Proteins are simple polymers with extraordinary properties of enormous biological and economic value. They are widely used in biological catalysis, as key components of analytical methods, or as highly specific drugs for personalized medicine. Protein engineering uses synthetic methods that allow the application of rational physicochemical knowledge and the power of evolutionary approaches to the goal of creating, in useful quantities, novel proteins that exhibit advantageous properties. In some cases, the challenge is to stabilize a natural protein for cheaper production, easier transport and storage, and longer operational life. In others, completely new properties are sought, which requires a greater amount of design. Significant advances in the understanding of protein energetics, in computational methods for sequence and structural analysis, and in synthetic methods, combined with growing economic and social interest in proteins, claim the logical transformation of Protein Engineering into a predictive quantitative discipline, where success is guaranteed by good design. In this Special Issue we will show, with examples of their application to specific proteins, the most advanced methods that anticipate the transformation of Protein Engineering from an art for practitioners to a reliable technology.
Prof. Dr. Javier Sancho
Prof. Dr. Francesca Cutruzzola
Guest Editors
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Keywords
- protein design
- computational methods
- evolutionary methods
- protein stabilization
- protein tailoring
- industrial proteins
- medicinal proteins
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