Role of the Mitochondrial Stress Response in Human Cancer Progression

Dear Colleagues,

Deregulation of cellular energetics has been identified as one of the hallmarks of cancer. Increasing evidence shows that somatic mutation in mitochondrial DNA (mtDNA), alteration in mtDNA copy number, mitochondrial enzyme defect, and mitochondrial dynamic change may contribute to mitochondrial dysfunction in cancer cells. Communication from mitochondria to the nucleus that is retrograde signaling is suggested to be involved in the mechanism that underlies mitochondrial dysfunction, ultimately promoting cancer malignant progression. Recent studies have suggested that several signaling pathways or mitochondrion-derived molecules might act as retrograde signaling regulators in the development and progression of cancer. However, the detailed molecular mechanisms by which alterations in mitochondrial function and metabolism promote cancer progression are cancer-type dependent and are yet to be studied.

In this Special Issue, we aim to promote the progression and development of the field relating to the role of mitochondria in cancer progression, as well as to the development of the strategies targeting the components of mitochondrial signaling for cancer treatment. We look for innovative research that is capable of dissecting the role of mitochondrial alteration or retrograde signaling in cancer progression. Original manuscripts and reviews dealing with any aspect of the role of alterations in mitochondrial function and metabolism involved in cancer malignant progression are welcomed.

Prof. Dr. Hsin-Chen Lee
Guest Editor

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