RNA-Binding Proteins—Structure, Function, Networks and Disease

Dear Colleagues,

RNA-binding proteins (RBPs) are key players for the post-transcriptional control of gene expression. They each bind to subpopulations of RNAs and thereby direct and coordinate the fate of all types of RNAs existing in our cells. RBPs control mRNA expression by guiding the processing, localisation, translation and eventual decay; and they collaborate with non-coding RNAs to achieve specific gene regulatory functions. The interest in RBPs is thus steadily increasing, revealing that they comprise a major class of proteins in all kingdoms of life and that they have widespread implications for cell homeostasis and differentiation, in both development and disease.

This issue intends to present up-to-date reviews about all aspects of RNA-binding proteins, providing an orientation point for investigation of this important class of biomolecules. We thus invite submissions of original research manuscripts (although review manuscripts are welcome as well) that cover but are not restricted to four main areas:

• Structural aspects of ribonucleoprotein complexes, RBPs or domains thereof; bioinformatics prediction of RBPs as well as engineering of RBPs and potential applications.
• Molecular functions of RBPs in post-transcriptional control of gene expression, including RNA processing, RNA export/localisation and decay, as well as translational control in eukaryotes or prokaryotes.
• Global-scale analysis of RBPs and their RNA targets; RNA-protein interaction networks and connectivity to other layers of cellular control.
• The role of RBPs in development and disease; transfer into clinical practice and drug development.

Prof. Dr. André P. Gerber
Guest Editor

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