Matrix Metalloproteinases in Health and Disease 4.0
A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Medicine".
Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 1299
Special Issue Editor
Interests: cardiovascular disease; vascular surgery; biomarkers
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Matrix metalloproteinases (MMPs) are members of an enzyme family that are critical for maintaining tissue allostasis. MMPs can catalyze the normal turnover of an extracellular matrix (ECM) together with other metalloproteinases such as the ADAMs (a disintegrin and metalloproteinase) and ADAMTS (a disintegrin and metalloproteinase with a thrombospondin motif) families. MMP activity is also regulated by a group of endogenous proteins, called tissue inhibitor of metalloproteinases (TIMPs). All these proteins have a pivotal role in normal physiological processes involving ECM remodeling, such as wound healing, embryogenesis, angiogenesis, bone remodeling, immunity, and the female reproductive cycle. An imbalance in the expression or activity of MMPs can also have important consequences in diseases such as cancer, cardiovascular disease, peripheral vascular disease, chronic leg ulcers, multiple sclerosis, and others.
In the last few years, MMPs have been found to have an important role in the field of precision medicine, as they may serve as biomarkers that may predict an individual’s disease predisposition, state, or progression. MMPs are also thought to be a sensible target for molecular therapy.
The aim of this Special Issue is to explore the most recent findings in this field that may have an impact on healthcare systems. Previous versions of this series of this Special Issue can be found here:
https://www.mdpi.com/journal/biomolecules/special_issues/Matrix_Metalloproteinases_3
https://www.mdpi.com/journal/biomolecules/special_issues/Matrix_Metalloproteinases_Health_Disease_2
https://www.mdpi.com/journal/biomolecules/special_issues/Matrix_Metalloproteinases_Health_Disease
We look forward to receiving your submission.
Prof. Dr. Raffaele Serra
Guest Editor
Manuscript Submission Information
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