S100 Proteins—Intracellular and Extracellular Function in Norm and Pathology 2.0

Dear Colleagues,

The S100 proteins, a branch of the family of Ca²⁺ -binding proteins counting more than 20 members and characterized by the presence of two EF-hands, do not cease to intrigue researchers since the discovery of its founding members nearly 60 years ago. Certainly one of the reasons is that, despite close sequence and structural similarity, the S100 proteins exhibit amazing versatility of interactions and biological functions. How this is achieved and how exactly the S100 proteins operate in a cell is still unclear. Do they only convey the Ca²⁺ signal to other molecules, or are they causative by themselves? Additionally, the use of novel research tools, including whole genome or proteome analyses, not only helped to confirm previous data on the involvement of individual S100 proteins in vital biological processes, but also uncovered novel pathways in which they may play an important role and thus opened new research areas.

All this prompted us to guest edit a second edition of the Special Issue of Biomolecules entitled “S100 Proteins—Intracellular and Extracellular Function in Norm and Pathology”. As before, the thematic scope is wide enough to cover many aspects of the biology of S100 proteins. We invite authors to publish recent research results and/or reviews concerning this topic in this issue of Biomolecules.

The exact information on terms and publication discounts can be obtained from the Guest Editors.

Prof. Dr. Wiesława Leśniak
Prof. Dr. Anna Filipek
Guest Editors

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