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Biomolecules
Special Issues
Molecular Mechanisms of Kidney Development and Diseases
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Molecular Mechanisms of Kidney Development and Diseases

A special issue of Biomolecules (ISSN 2218-273X). This special issue belongs to the section "Molecular Medicine".

Deadline for manuscript submissions: closed (30 November 2022) | Viewed by 3485

Special Issue Editor

Prof. Dr. Gregory B Vanden Heuvel

E-Mail Website
Guest Editor
Department of Biomedical Sciences, Western Michigan University Homer Stryker M.D. School of Medicine, Kalamazoo, MI 49008, USA
Interests: renal development; polycystic kidney disease; cell biology; cell cycle regulation

Special Issue Information

Dear Colleagues,

The mammalian kidney is one of the most complex organs in the body. In addition to filtering the blood to remove wastes, the kidney is the major homeostatic organ necessary for pH and electrolyte regulation, maintains overall fluid balance to regulate blood pressure, and plays an endocrine role though the production of hormones.

Classical developmental biology studies have revealed that the kidney develops from the interaction of two types of progenitor cells in the intermediate mesoderm: the epithelial ureteric bud and an undifferentiated patch of mesenchymal cells called the metanephric mesenchyme. The interaction between these two tissue types initiates a process of mesenchymal-to-epithelial transformation, which results in the generation of the nephron, the basic functional unit of the kidney. There are numerous specialized cell types in the nephron that interact in kidney function. These various cells types have been identified based on morphological features associated with unique functions. Recent advancements in single-cell multiomics of developing and mature kidneys have revealed a complexity of gene expression that defines the specialized cell types within the nephron and provides an opportunity for a better understanding of the development of the kidney and how disruption of these processes contributes to disease. In this Special Issue, we will highlight and review new research on the molecular mechanisms of kidney development and disease.

Prof. Dr. Gregory B Vanden Heuvel
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Biomolecules is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Cux1
  • Hox
  • homeobox
  • kidney development

Published Papers (2 papers)

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Research

19 pages, 5604 KiB  
Article
Spatio-Temporal Expression Pattern of CAKUT Candidate Genes DLG1 and KIF12 during Human Kidney Development
by Daniela Veljačić Visković, Mirela Lozić, Martina Vukoja, Violeta Šoljić, Katarina Vukojević, Merica Glavina Durdov, Natalija Filipović and Bernarda Lozić
Biomolecules 2023, 13(2), 340; https://doi.org/10.3390/biom13020340 - 9 Feb 2023
Cited by 4 | Viewed by 1548
Abstract
We aimed to investigate expression of the novel susceptibility genes for CAKUT, DLG1 and KIF12, proposed by a systematic in silico approach, in developing and postnatal healthy human kidneys to provide information about their spatiotemporal expression pattern. We analyzed expression of their [...] Read more.
We aimed to investigate expression of the novel susceptibility genes for CAKUT, DLG1 and KIF12, proposed by a systematic in silico approach, in developing and postnatal healthy human kidneys to provide information about their spatiotemporal expression pattern. We analyzed expression of their protein products by immunohistochemistry and immunofluorescence and quantified relative mRNA levels by RT-qPCR. Statistically significant differences in expression patterns were observed between certain developmental stages. Strong expression of DLG1 was observed in the developing kidney, with a gradual decrease from the first phase of kidney development (Ph1) until the third phase (Ph3), when most nephrons are formed; at later stages, the highest expression was observed in the tubules. KIF12 was highly expressed in the developing structures, especially in Ph1, with a gradual decrease until the postnatal phase, which would indicate a significant role in nephrogenesis. Co-localization of DLG1 and KIF12 was pronounced in Ph1, especially on the apical side of the tubular epithelial cells. Thereafter, their expression gradually became weaker and was only visible as punctate staining in Ph4. The direct association of DLG1 with KIF12 as control genes of normal kidney development may reveal their new functional aspect in renal tubular epithelial cells. Full article
(This article belongs to the Special Issue Molecular Mechanisms of Kidney Development and Diseases)
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13 pages, 2996 KiB  
Article
Bim Expression Modulates Branching Morphogenesis of the Epithelium and Endothelium
by Christine M. Sorenson, Yong-Seok Song, Shoujian Wang, Soesiawati R. Darjatmoko, Mohammad Ali Saghiri, Mahsa Ranji and Nader Sheibani
Biomolecules 2022, 12(9), 1295; https://doi.org/10.3390/biom12091295 - 14 Sep 2022
Viewed by 1561
Abstract
Branching morphogenesis is a key developmental process during organogenesis, such that its disruption frequently leads to long-term consequences. The kidney and eye share many etiologies, perhaps, due to similar use of developmental branching morphogenesis and signaling pathways including cell death. Tipping the apoptotic [...] Read more.
Branching morphogenesis is a key developmental process during organogenesis, such that its disruption frequently leads to long-term consequences. The kidney and eye share many etiologies, perhaps, due to similar use of developmental branching morphogenesis and signaling pathways including cell death. Tipping the apoptotic balance towards apoptosis imparts a ureteric bud and retinal vascular branching phenotype similar to one that occurs in papillorenal syndrome. Here, to compare ureteric bud and retinal vascular branching in the context of decreased apoptosis, we investigated the impact of Bim, Bcl-2’s rival force. In the metanephros, lack of Bim expression enhanced ureteric bud branching with increases in ureteric bud length, branch points, and branch end points. Unfortunately, enhanced ureteric bud branching also came with increased branching defects and other undesirable consequences. Although we did see increased nephron number and renal mass, we observed glomeruli collapse. Retinal vascular branching in the absence of Bim expression had similarities with the ureteric bud including increased vascular length, branching length, segment length, and branching interval. Thus, our studies emphasize the impact appropriate Bim expression has on the overall length and branching in both the ureteric bud and retinal vasculature. Full article
(This article belongs to the Special Issue Molecular Mechanisms of Kidney Development and Diseases)
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