Perivascular Adipose Tissue and Protease-Activated Receptor 2 (PAR2): Molecules and Signalling in Metabolic Syndrome
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".
Deadline for manuscript submissions: 30 July 2024 | Viewed by 184
Special Issue Editors
2. Department of Physiology & Pharmacology, Schulich School of Medicine & Dentistry, Western University, London, ON N6A 5C1, Canada
Interests: endothelium; vascular smooth muscle; G-protein-coupled receptors; peptides; blood vessels
Interests: perivascular adipose tissue; protease-activated receptor 2; metabolic syndrome; vascular endothelium; cardiovascular function
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Metabolic syndrome (MetS) increases the risk of heart, blood vesel, kidney and cerebrovascular diseases. Furthermore obesity, type 2 diabetes and lipidemia associated with MetS affect the adipose tissue surrounding visceral organs and blood vessels, i.e., perivascular adipose tissue (PVAT). Bioactive substances, for example, metabolites, adipokines, proteases and gaseous transmitters generated by PVAT are known to modulate circulatory system function, including local vascular tone and wall remodeling, and contribute to cardiac and vascular complications. Studies in various animal models provide evidence that cell receptors such as the G-protein-coupled receptor protease-activated receptor 2 (PAR2) participate in the inflammatory pathological conditions of MetS and obesity. Thus, PVAT can be a source and target of molecular signals in health and disease.
This Special Issue will look at the characterizations of the molecules and signaling underpining the roles played by PVAT in MetS. Studies elaborating on the theme of protease-activated receptor 2 are particularly encouraged. We welcome original research articles and reviews covering the research areas, especially preclinical models and novel molecules, focused on therapeutics. We hope this Special Issue provides insights into the molecular signaling and function of PVAT and opportunities for discussion of new approaches to the prevention and treatment of MetS complications.
Dr. John J. McGuire
Dr. Satomi Kagota
Guest Editors
Manuscript Submission Information
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Keywords
- perivascular adipose tissue
- protease-activated receptor 2
- metabolic syndrome
- inflammations
- adipokines
